p53高表达与林县食管癌及其危险因素关系的分子流行病学研究  

THE RELATIONSHIPS BETWEEN OVEREXPRESSION OF p53 BOTH AND ESOPHAGEAL CANCER(EC) AND THE RISK FACTORS OF EC IN LIN COUNTY

作　　者：张秀玲[1,2] 徐德忠[1,2] 常贵生 杨文献[1,2] 李良寿[1,2] 孙长生[1,2] 阎明晓[1,2] 王嫣 

机构地区：[1]第四军医大学流行病学教研室 [2]河南省肿瘤研究所

出　　处：《解放军预防医学杂志》1997年第5期337-341,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：国家自然科学基金

摘　　要：采用免疫组化方法和流行病学病例对照研究，对ｐ５３高表达与林县食管癌及其危险因素间的关系进行了探讨。结果发现ｐ５３高表达与林县食管癌间存在强的联系，单因素和多因素Ｌｏｇｉｓｔｉｃ回归分析ＯＲ值分别为７．０３（９５％可信限２．３３～２２．２１）和５．０７（Ｐ＝０．００７３），食管癌家族史和食用酸莱与ｐ５３高表达具有协同作用。而且还发现食管癌家族史为ｐ５３高表达的危险因素（ＯＲ＝１．３７，Ｐ＝０．０６７１）。结果提示，在暴露于危险因素至癌变过程中，ｐ５３基因异常可能起着重要作用。这为林县食管癌的病因学和发病机理提供了一定的分子水平依据。 The relationships between overexpression of p53 both and esophageal cancer(EC) and the risk factors of EC in Lin County, Henan provine, were studied with method of molecular epidemiology. The results showed that there was strong association between overexpression of p53 with EC. Odd ratios(OR) yielded from uni-and multi-factor logistic regression analysis were 7.03(95% CI 2.37-22.21) and 5.07(P=0.0075) respectively. Both family history of EC and pickled vegetable consumption showed a synergetic effect with overexpression of p53 on the incidence of EC. And family history also was a risk factor of overexpression of p53. These results indicated that abnormal of p53 tumor suppressor gene may play an important role from exposure of risk factors to carcinogenesis of EC.

关 键 词：食管肿瘤 P53基因 分子流行病学 危险因素 

分 类 号：R735.101[医药卫生—肿瘤]