睾丸精原细胞瘤免疫表型及临床病理分析  

The Immunophenotype and Clinicopathological Featuers of Testicular Seminoma

作　　者：李志义[1] 张著学[1] 刘斌[1] 吴启峰[1] 

机构地区：[1]贵阳市第一人民医院病理科,550002

出　　处：《实用癌症杂志》2008年第5期478-479,482,共3页The Practical Journal of Cancer

摘　　要：目的探讨睾丸精原细胞瘤的免疫表型、临床病理特征、诊断和鉴别诊断。方法通过光镜观察和多种免疫组化标记,分析8例睾丸精原细胞瘤病理组织学特征和免疫组化在诊断和鉴别诊断中的意义。结果8例睾丸精原细胞瘤,平均年龄41.4岁,巨检肿瘤均呈类长椭圆形,最大径平均10.4 cm,包膜完整,切面灰白色鱼肉状;镜下均表现为典型精原细胞瘤的病理组织学特征;免疫组化PLAP、D2-40、CD117均为强阳性(8/8),其中2例HCG-α阳性,1例CD30阳性;而AFP、CK-LMW及Vim均为阴性(8/8)。结论睾丸精原细胞瘤好发于中年男性,其诊断主要依据典型的病理组织学特征和免疫组化检测,免疫标记物PLAP、D2-40、CD117、CD30、HCG和AFP在诊断和鉴别诊断中具有重要作用。Objective To explore the immunophenotype,clinicopathological features, diagnosis and differential diagnosis of testicular seminoma. Methods 8 patients with testicular seminoma were analyzed with light microscopy and immunohistochemistry. Results The average age was 41.4 years. The tumors were in long ovoid, and the average large diameter was 10.4 cm. The cut surfaces of tumors were gray white with complete membrane. Histological examine showed typical seminoma. Immunohistochemically, tumor cells were positive for PLAP, D2-40, CD117 （ 8/8 ）, HCG-α （ 2/8 ）, CD30 （ 1/8 ）, but were negative for AFP, CKLMW, Vim（ 8/8 ）. Conclusion Testicular seminoma often seen in middle-aged male. The definitive diagnosis should be based on histopathological features and immunohistochemieal study. Combined analyses of PLAP, D240, CD117, CD30, HCG, AFP has important role in the differential diagnosis of testicular tumors.

关 键 词：睾丸肿瘤 精原细胞瘤 免疫组化 

分 类 号：R737.21[医药卫生—肿瘤]