钙结合蛋白和乙酰肝素酶在肿瘤转移中的研究进展  

The Study Advancement of S100A4 and Heparanase-1 in Invasion and Metastasis of Malignant Cancer

作　　者：高川[1] 张明亮[1] 

机构地区：[1]南华大学附属二医院消化内科,湖南衡阳421001

出　　处：《医学综述》2008年第18期2758-2761,共4页Medical Recapitulate

摘　　要：侵袭和转移是恶性肿瘤最重要最本质的特征。钙结合蛋白(S100A4)基因是近几年发现的一种具有促肿瘤作用的基因,该基因编码一种钙离子结合调节蛋白,通过与钙离子结合在肿瘤的侵袭转移中发挥重要作用。乙酰肝素酶(HPA)是裂解硫酸乙酰肝素蛋白多糖的惟一酶类,能破坏细胞外基质及基底膜,参与血管生成,与肿瘤的侵袭转移密切相关。本文综述了S100A4蛋白和HPA的生物学特征及在肿瘤中的作用,并探讨了其可能的作用机制。The invasion and metastasis plays an important action in progress of malignant tumor. S100A4 gene is a new found gene which can promote the progress of tumor in recent several years. The gene encodes a calciun-binding protein whichplays a important action in progress of tumor by binding with calcium ions. Heparanase was an endo- D-glucuronidase that can cleave heparan sufatprotroglycans and has been implicated in tumor angiogenesis and metastasis. Below we disscuss its biochemical properties and possible cellular functions in metastasis including cell motility,invasion, apoptosis and angiogenesis.

关 键 词：恶性肿瘤 钙结合蛋白 乙酰肝素酶 肿瘤侵犯转移 

分 类 号：R730.22[医药卫生—肿瘤]