缬草对慢性应激导致的抑郁大鼠体质量和行为的影响  

Effects of Valerian on Weight and Behavior of Depressive Rats Induced by Chronic Mild Stress

作　　者：唐久余[1] 曾园山[1] 陈巧格[1] 秦亚静[1] 陈穗君[1] 钟志强[1] 

机构地区：[1]中山大学中山医学院组织胚胎学教研室神经科学研究室,广东广州510080

出　　处：《中山大学学报（医学科学版）》2008年第5期541-545,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省中医药管理局科研基金(101139)

摘　　要：【目的】探讨缬草对慢性应激导致的抑郁大鼠体质量和行为的影响。【方法】70只大鼠随机分为低、中和高剂量缬草模型组、阳性对照模型组、阴性对照模型组、未用药模型组和正常对照组各10只。给予各模型组大鼠慢性应激4周建立抑郁症模型。模型建立后除未用药模型组大鼠正常饲养外,其余6组相应灌服低、中和高剂量缬草、氟西汀(阳性对照)和羧甲基纤维素钠(阴性对照)等药物3周。每周测定大鼠的体质量、自来水摄取量和10g/L糖水摄取量。【结果】灌服低、中和高剂量缬草以及阳性对照药氟西汀均不能促使抑郁大鼠的体质量恢复至正常大鼠水平。在整个实验期间,7组大鼠之间自来水摄取量的差异无统计学意义。氟西汀与低剂量缬草能够促使抑郁大鼠的糖水摄取量恢复性增加到正常大鼠水平。【结论】一定剂量的缬草能够促使抑郁大鼠恢复正常的行为活动。[Objective] To explore the effects of Valerian on the weight and behavior of depressive rats induced by chronic mild stress. [Methods] A total of 70 rats were divided randomly into low dose of Valerian model group, medium dose of Valerian model group, high dose of Valerian model group, positive control model group, negative control model group, untreated model group, and normal control group. Each group had 10 rats. Each model group of rats were induced into depressive disorder by chronic mild stress for 4 weeks. After that,except the untreated model group, the other six groups were administrated respectively by low, medium, and high dose of Valerian, fluoxetine, and sodium earboxymethyeellulose for 3 weeks. The weight, tap water intake and 10 g/L sucrose intake were weekly examined for seven groups of rats. [Results] After the intragastrie administration of low, medium, and high dose of Valerian, and fluoxetine （a positive control drug）, the weight of depressive rats did not recover to that of normal control group of rat. Tap water intake was not statistically different between seven groups of rats during the experimentation. However, 10 g/L sucrose intake in fluoxetine model group and low dose of Valerian model group was increased and recovered to that of normal control group of rat. [Conclusion] A certain dose of Valerian may make behavior of depressive rats to recover to normal status.

关 键 词：慢性应激 抑郁症 缬草 体质量 行为学 

分 类 号：R749[医药卫生—神经病学与精神病学]