VEGF-C和VEGFR-3在人结肠癌组织中的表达及意义  

Expression of VEGF-C and VEGFR-3 in Human Colon Carcinoma and Its Significance

作　　者：王璟璐[1] 邢丽娜[1] 

机构地区：[1]哈尔滨医科大学附属第二医院放射治疗科,哈尔滨市150081

出　　处：《中国肿瘤临床》2008年第16期910-913,共4页Chinese Journal of Clinical Oncology

基　　金：黑龙江省科技厅科研基金资助(编号:NoGC03C606-1)

摘　　要：目的:探讨血管内皮生长因子C(VEGF-C)及其受体3(VEGFR-3)在结肠癌淋巴管生成及淋巴道转移中的作用。方法:取55例人结肠癌组织样本,应用免疫组6织化学法,观察VEGF-C和VEGFR-3在人结肠癌组织中的表达,应用Podoplanin标记淋巴管,检测结肠癌组织中的微淋巴管密度。结果:55例结肠癌组织中,VEGF-C阳性表达率为61.8%,明显高于癌周正常组织内的表达(P<0.05);结肠癌组织中VEGFR-3表达的阳性率为69.1%,明显高于癌周正常组织(P<0.01)。经计数淋巴管数量,癌组织中的LMVD明显高于癌周正常组织(P<0.01),并且LMVD与VEGF-C的表达显著相关(P<0.01)。结论:VEGF-C通过与VEGFR-3的结合促进癌组织中淋巴管的生成,使癌组织中LMVD增高,对肿瘤细胞发生淋巴道转移起促进作用。Objective： To investigate the role of vascular endothelial growth factor C （VEGF-C） and vascular endothelial growth factor receptor 3 （VEGFR-3） in lymphangiogenesis and lymphatic metastasis of human colon carcinoma. Methods： The expression of VEGF-C and VEGFR-3 were detected by SP immunohistochemical staining in 55 human colon carcinoma samples. Lymphatic vessels were identified by Podoplanin in colon carcinoma. Results： The positive expression rate of VEGF-C in colon carcinoma （61.8%） was significantly higher than in adjacent normal tissues （P〈0.05）. The expression rate of VEGFR-3 in colon carcinoma （69.1%） was also higher than in adjacent normal tissues （P〈0.01）. Lymphatic vessel density （LMVD） in carcinoma was significantly higher than in adjacent normal tissues. A correlation was found between LMVD and the expression of VEGF-C. Conclusion： VEGF-C can induce tumor lymphangiogenesis through its receptor VEGFR-3. VEGF-C and VEGFR-3 may play an important role in lymphatic metastasis of human colon carcinoma.

关 键 词：结肠癌 VEGF—C VEGFR-3 PODOPLANIN 

分 类 号：R735.35[医药卫生—肿瘤]