VEGF和MMP-2表达与肝细胞肝癌复发和预后的关系  

Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Hepatocellular Carcinoma and Its Relationship with Rucurrence and Prognosis

作　　者：赵秀兰[1] 杜静[2] 赵学铭[1] 沈军[1] 倪春生[1] 赵楠[1] 孙保存[1] 

机构地区：[1]天津医科大学病理教研室,天津市300070 [2]天津市中心妇产科医院病理科

出　　处：《中国肿瘤临床》2008年第16期934-937,共4页Chinese Journal of Clinical Oncology

基　　金：天津市科委自然科学基金(编号:023616511);天津市教委自然基金资助(编号:20040116)

摘　　要：目的:研究血管内皮生长因子(VEGF)和基质金属蛋白酶2(MMP-2)在肝细胞肝癌(HCC)中的表达与HCC复发转移的关系。方法:按是否复发将93例肝癌患者分为复发组与未复发组,采用免疫组化方法检测两组标本中VEGF及MMP-2的表达情况,分析两者的表达与临床病理指标的关系。结果:VEGF与MMP-2在93例HCC中的阳性表达率分别为52.69%与67.74%,复发组(44例)的阳性表达率分别为68.18%(30/44)、88.64%(39/44);未复发组(49例)的阳性表达率分别为36.78%(19/49)、48.98%(24/49),两组之间差异具有统计学意义(P<0.05)。生存分析显示术后两年生存率MMP-2(+)与(-)组分别为41.42%、63.36%,差异具有统计学意义(P<0.05);VEGF(+)与(-)两年生存率分别为48.50%、52.21%,差异不具有统计学意义(P>0.05)。结论:MMP-2表达高的肝癌,转移复发率高,预后差。Objective： To investigate the expression and clinical impact of vascular endothelial growth factor （VEGF） and matrix metalloproteinase 2 （MMP-2） in hepatocellular carcinoma （HCC）. Methods： We collected 93 HCC resection samples with complete clinical and prognostic data. Immunohistochemical staining of VEGF and MMP-2 were conducted in recurrent group （44） and non-recurrent group （49）. Correlations of the expression of MMP-2 and VEGF with clinicopathologic features were analyzed. Results： The positive rates of VEGF and MMP-2 expression in HCC tissues were 52.69% and 67.74%, respectively. These two indices were expressed in cytoplasm. The positive rates of VEGF and MMP-2 were significantly higher in recurrent group than in non-recurrent group （68.18% vs. 88.64%; 36.78% vs. 48.98%）. The 2-year tumor free survival rates of MMP-2 （＋） group and MMP-2 （-） group were 41.42% and 63.36%, respectively. The MMP-2 （＋） group has a lower survival rate than the MMP-2 （-） group （P=0.0142）. The 2-year survival rates of VEGF （＋） group and VEGF （-） group were 48.50% and 52.21%, respectively, with no statistical significance （P=0.1834）. Conclusion： HCC which highly expresses MMP-2 has a higher rate of recurrence, a lower survival rate, and a poorer prognosis. The expression of MMP-2 can be used to estimate the risk of postoperative recurrence of HCC.

关 键 词：血管内皮生长因子 基质金属蛋白酶2 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]