Albaconol,a Plant-Derived Small Molecule,Inhibits Macrophage Function by Suppressing NF-κB Activation and Enhancing SOCS1 Expression  

作　　者：Qiuyan Liu Xiaoli Shu Li Wang Anna Sun Jikai Liu Xuetao Cao 

机构地区：[1]Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, China [2]Institute of Immunology, Zhejiang University, Hangzhou 310031, China [3]State Key Laboratory of Phytochemistry and Plant Resourses in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China

出　　处：《Cellular & Molecular Immunology》2008年第4期271-278,共8页中国免疫学杂志（英文版）

基　　金：grants from the National Natural Science Foundation of China (30721091);the National Key Basic Research Program of China (2007CB512403)

摘　　要：Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 μg/ml, inhibited proliferation of RAW264.7 cells in a doseand time-dependent manner, and could induce cellular apoptosis when used at high dosage （≥7.5 μg/ml）. Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-α IL-6, IL-1β and NO production in RAW264.7 cells. The inhibition of NF-κB activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti- inflammatory drug. Cellular ＆ Molecular Immunology. 2008;5（4）：271-278.Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 μg/ml, inhibited proliferation of RAW264.7 cells in a doseand time-dependent manner, and could induce cellular apoptosis when used at high dosage （≥7.5 μg/ml）. Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-α IL-6, IL-1β and NO production in RAW264.7 cells. The inhibition of NF-κB activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti- inflammatory drug. Cellular ＆ Molecular Immunology. 2008;5（4）：271-278.

关 键 词：IMMUNOSUPPRESSANT MACROPHAGE proinflammatory cytokine NF-ΚB SOCS 1 

分 类 号：TQ460.38[化学工程—制药化工] R392.1[医药卫生—免疫学]