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机构地区:[1]清华大学化学系,北京100084
出 处:《化学研究与应用》2008年第9期1216-1219,共4页Chemical Research and Application
摘 要:The novel compounds 7-Methoxy-4-oxo-6-pivalamide-1,4-dihydroquinazoline(10)and 4-chloro-7-methoxy-6-pivalamidoquinazoline(11)are synthesized in ten steps from 4-methoxybenzoic acid.During the synthesis,protective and deprotective methods are employed in the nitration and reduction steps.This new functionalized quinazoline entity can be modified with other active moieties,which may have special antitumor activities.The novel compounds 7-Methoxy-4-oxo-6- pivalamide-1, 4-dihydroquinazoline ( 10 ) and 4-chloro-7-methoxy-6- pivalamidoquinazoline( 11 )are synthesized in ten steps from 4-methoxybenzoic acid. During the synthesis, protective and deprotective methods are employed in the nitration and reduction steps. This new functionalized quinazollne entity can be modified with other active moieties, which may have special antitumor activities.
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