NF-κB在卵巢癌顺铂耐药株COC1/DDP中的表达及意义  

Expression and significance of NF-κB in the cisplatin-resistant cell line COC1/DDP

作　　者：何凯[1] 雷娟[1] 卢战凯[1] 许天敏[2] 李源[3] 李云波[4] 张雪芹[1] 杜绍敏[1] 

机构地区：[1]大庆油田总医院集团龙南医院齐齐哈尔医学院第五附属医院妇产科,黑龙江大庆163000 [2]吉林大学第二医院妇产科 [3]首都医科大学附属北京妇产医院 [4]北京中医药大学第三医院妇产科

出　　处：《中国实验诊断学》2008年第9期1113-1114,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨NF-κB在卵巢癌COC1/DDP顺铂耐药中的生物学作用。方法应用Westernblot法检测COC1、COC1/DDP两细胞株细胞核内NF-κB p65蛋白表达差异。结果COC1/DDP细胞核内NF-κB p65蛋白表达明显高于亲本株COC1。结论COC1/DDP对顺铂耐药可能与NF-κB核内活化表达有关。Objective To invastigate the role of NF-κB in the cisplatin-resistanee of ovarian cancer cell line COC1/DDP. Methods Westemblot was used to detect the expression of NF-κ B p65 in the nucleus of COC1 and COC1/DDP. Results The expression of NF-κ B p65 in the nucleus of COC1/DDP is significantly higher than that in the COC1. Conclusion The cisplatin resis- tance of COC1/DDP is related with the activated expression of NF-κ B in the nucleus.

关 键 词：NF-ΚB 卵巢癌 耐药 顺铂 

分 类 号：R737.31[医药卫生—肿瘤]