中医药综合疗法对脑出血阳类证患者神经功能改善及生活质量的影响  

Effects of Comprehensive Chinese Medical Protocol on Nerve Function Improvement and Quality of Life in Hypertensive Intracerebral Hemorrhage of Yang-Like Syndromes

作　　者：卢明[1] 杜宝新[1] 黄培新[1] 黄燕[1] 欧爱华[1] 

机构地区：[1]广东省中医院脑病专科,广东广州510120

出　　处：《上海中医药杂志》2008年第9期16-19,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金："十五"国家科技攻关项目(2001BA701A12B);广东省科技计划项目(2002C30602);国家中医药管理局基金资助项目(02-03LQ006)

摘　　要：目的观察中医药综合疗法治疗高血压性脑出血中风阳类证患者的临床疗效。方法采用多中心随机对照试验方法,将343例患者随机分为综合组178例和对照组165例,分别采用中医药综合疗法(包括对症支持、康复治疗以及清热平肝、破瘀涤痰、通腑醒神治法下的静脉、口服中成药等的阳类证辨证综合疗法)、对照治疗(包括对症支持、康复治疗及中药安慰剂);治疗28天及随访3个月评价临床疗效、神经功能缺损改善及相关生活质量指标。结果343例患者中,28天内脱落23例,死亡30例;随访290例,死亡11例,失访8例。治疗后28天愈显率综合组为58.0%,对照组为50.4%;病死率综合组为11.3%,对照组为8.8%;两组差异无统计学意义(P>0.05)。3个月后随访愈显率综合组为85.4%,对照组为74.6%,两组比较,差异有统计学意义(P<0.05)。治疗28天神经功能缺损评分、ADL等级积分、BI指数、QLI评分、FAQ评分改善比较,两组差异无统计学意义(P>0.05);治疗后3个月随访,差异均有统计学意义(P<0.05)。结论多中心质量控制下的中医药综合疗法,可提高高血压性出血中风阳类证患者远期的临床疗效和生活质量。Objective To observe the effects in hypertensive intracerebral hemorrhage （ICH） patients differentiated as yang-like syndromes with comprehensive protocol of traditional Chinese medicine （CPTCM）.Mcthods A multi-center randomized and controlled clinical trail was adopted, 343 ICH patients were divided into treatment group （178 cases） treated with CPTCM protocol （including traditional Chinese medicine on differentiation）, and control group （165 cases） treated with western medicine plus placebo to compare clinical curative effect, never function failure （NF）, Barther index （BI）, quality of life index （QLI）, ability diary of life （ADL）, and functional activities questionnaire （FAQ） on the 28th day and the third month. Results 23 dropped, 30 died in the 28 days; 290 followed in the 3rd month and 11 died, 8 dropped.The good improvement rate of treatment group was 85.4% in the third month, with a significant difference than 74.6% of the control group（P〈0.05）, but there was no significant differencgP〉0.05） on the 28th day after treatment. NF, BI rate. QLI and FAQ grades of two groups had no differences （P〉 0.05） on the 28th day after treatment; but those of treatment group were better than those of the control group, there was a significant difference （P〈 0.05） in the third month after treatment. Conclusion CPTCM has good effects in ICH patients differentiated as yang-like syndromes in clinical efficacy and quality of life.

关 键 词：脑出血 阳类证 中西医结合疗法 

分 类 号：R743.34[医药卫生—神经病学与精神病学]