Survivin表达与胃癌的生物学行为  

The relationship between Survivin expression and biological behavior in gastric carcinoma

作　　者：钟琼[1] 钟芬梅[2] 肖震宇[1] 刘国焰[1] 

机构地区：[1]江西省赣州市人民医院 [2]江西理工大学医院,江西赣州341000

出　　处：《赣南医学院学报》2008年第4期532-533,共2页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:研究胃癌组织中Survivin表达和临床病理因素的关系。方法:采用免疫组织化学S-P法检测20例正常胃黏膜及80例胃癌组织中Survivin表达。结果:20例正常胃粘膜Survivin均不表达,胃癌组织中Survivin阳性率为65%(52/80),二者有显著性差异(P<0.01);Survivin表达与组织分化程度和TNM分期密切相关(P<0.05)。结论:Survivin在胃癌中过表达,Survivin表达与胃癌的临床病理特征密切相关,Survivin可能是临床评价胃癌恶性程度的重要指标。Objective：To sdudy the relation between Survivin expression and the clinicopathologic characters of gastric carcinoma. Methods： Survivin were examined with immunohistochemical S - P method in 20 specimens of normal gastric mucosa and 80 specimens of gastric cacinoma. Results：All normal mucosas were negative for survivin. In the 80 gastric carcinomas ,65% （52/80） was postive for survivin（P 〈0.01 ）. The expression of survivin was significantly related with histological differentiation and TNM stage（ P 〈 0.01 ）. Conclusion：Survivin was overexpressed in gastric cancer. Survivin expression is well associated with the clinicopathologic characters of gastric carcinoma. It may be valuable to evaluate the malignant degree of gastric carcinoma.

关 键 词：胃癌 SURVIVIN 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]