卡介苗溶菌黏膜免疫调理剂对激活荷瘤小鼠免疫功能的研究  

Study of broken-BCG mucous membrane immune modifier(BCG-b) for activating immune-response in tumor mice

作　　者：邹宇玲[1] 贾淑珍[1] 寇丽杰[1] 乔莱艳[1] 黄建[1] 王国治[1] 

机构地区：[1]中国药品生物制品检定所,北京100050

出　　处：《微生物学免疫学进展》2008年第3期7-9,共3页Progress In Microbiology and Immunology

摘　　要：观察卡介苗溶菌黏膜免疫调理剂对荷瘤小鼠免疫功能的激活。将SPF小鼠分组后用黑色素瘤B16和肝癌实体瘤H22感染,随后以灌胃途径引入本调理剂,分别发现它能促进荷瘤小鼠血清溶菌酶含量上升和T细胞介导的迟发型变态反应增强。试验结果表明,卡介苗溶菌黏膜免疫调理剂对荷瘤小鼠有升高其血清溶菌酶含量和增强迟发型变态反应的作用。To study the function of a newly developed “broken BCG mucous membrane immune modifier （BCG-b） ,” the immune-response in two mouse models was tested, one was infected with a cell line of melanoma B16 tumor and the other,with liver cancer H22 tumor cells. The results showed that the BCG-b may increase the activity of serum lysozyme and DTH in B16-infected mice and H22-infected mice, respectively.

关 键 词：卡介苗溶菌黏膜免疫调理剂 荷瘤小鼠 溶菌酶 迟发型变态反应 

分 类 号：R392[医药卫生—免疫学] R730.5[医药卫生—基础医学]