萝卜过氧化物酶的毒理学研究  

Toxicology of Radish Peroxidase in Mice

作　　者：刘伟[1] 王丽[1] 孙向东[1] 宗秀征[1] 杨少华[1] 李芳军[1] 李小娟[1] 王林嵩[1] 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007

出　　处：《四川动物》2008年第5期939-940,共2页Sichuan Journal of Zoology

基　　金：国家自然科学基金(30570135)

摘　　要：为了探讨萝卜过氧化物酶应用的安全性,对其进行了小鼠经口急性毒性实验、小鼠骨髓嗜多染红细胞微核实验和小鼠精子畸形实验等急性和遗传毒性实验。结果表明,受试物对小鼠的LD50(半数致死剂量)大于10.0g/kg体重,属实际无毒物质。小鼠骨髓嗜多染红细胞微核实验及小鼠精子畸形实验结果均为阴性。受试物未显示有遗传毒性。To evaluate the safety of radish peroxidase, the acute oral toxicity, bone marrow cell micronucleus and sperm abnormality were determined in mice. The result showed that the LD50 of radish peroxidase was more than 10.0 g/kg body weight, which can be regarded as virtually non-toxic. The results were all negative in bone marrow micronucleus and spei＇m abnormality tests. It can be concluded that radish peroxidase is not a substance with acute and genetic toxicity under the test condition.

关 键 词：萝卜过氧化物酶 急性毒性 遗传毒性 

分 类 号：R114[医药卫生—卫生毒理学]