Ⅱ型ZTC1+1天然澄清剂用于驴胶补血颗粒水提液的澄清工艺研究  

Optimum clarification process of Lvjiao buxue granules with ZTC1+1-Ⅱ natural clarifying agents

作　　者：严建业[1] 颜红[1] 夏新华[1] 王艳平[2] 熊飞燕[2] 

机构地区：[1]湖南中医药大学药学院药剂教研室,长沙410208 [2]湖南中医药大学,2005级研究生长沙410007

出　　处：《中南药学》2008年第5期519-523,共5页Central South Pharmacy

基　　金：国家"十五"科技攻关课题;资助项目编号:2001BA701A48;湖南省教育厅科研项目;课题编号:07C497

摘　　要：目的优选ZTC1+1-Ⅱ用于驴胶补血颗粒水提液的最佳澄清工艺。方法实验通过ZTC1+1-Ⅱ澄清剂A、B两组分的加入顺序、用量、药液浓度、温度、搅拌等为影响因素,在单因素分析的基础上应用正交实验设计优化了澄清工艺条件。结果优选出的最佳工艺条件为:提取液浓缩至1∶7,温度:60℃,搅拌速度:150 r.min-1,先加ZTC A组分0.3 mL.g-1,后加B组分0.15 mL.g-1。结论ZTC1+1-Ⅱ天然澄清剂的澄清工艺可用于驴胶补血颗粒的除杂。Objective To determine the optimum process with ZTC1 ＋1-Ⅱ natural clarifying agents for Lvjiao buxue granules. Methods Based on the effect of some factors such as the adding sequence of ZTC1 ＋1-Ⅱ clarifiers A and B, the amount, the concentration of the extracting solution, the temperature and whisking speed etc, orthogonal design was selected to decide the best clarification process with ZTC1 ＋1-Ⅱ natural clarifying agents for Lvjiao huxue granules. Results The optimal process was condensing the extract solution to 1 ： 7 （herb： herb solution）, the flocculation temperature was 60 ℃, the whisking speed was 150 r · min^-1 , the sequence of ZTC1 ＋1-Ⅱ natural clarifying agents was elarifier A before elarifier B. The optimun amount of ZTC clarifier was 0.3 mL · g^-1 for clarifier A and 0.15 mL · g^- 1 for clarifier B. Conclusion Removing impurity with ZTC1 ＋1-Ⅱnatural clarifying agents can be used for Lvjiao buxue granules.

关 键 词：驴胶补血颗粒 ZTC1+1-Ⅱ 澄清工艺 阿魏酸 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学]