耐药基因TopoⅡ及Ki-67在食管鳞癌的表达  

The Expression of Topo Ⅱ and Ki-67 in Esophageal Squamous Cell Carcinoma

作　　者：柳维军 阳云平[2] 徐志强[2] 

机构地区：[1]遂宁市中医院病理科,四川遂宁62900 [2]仪陇县人民医院,四川仪陇637600

出　　处：《西南军医》2008年第5期8-9,共2页Journal of Military Surgeon in Southwest China

摘　　要：目的探讨TopoⅡ及Ki-67在食管鳞癌的表达及其与肿瘤分化程度、淋巴结转移的关系。方法应用免疫组化检测75例食管鳞癌组织中TopoⅡ和Ki-67的表达情况。结果TopoⅡ和ki-67的表达与食管鳞癌的组织分化程度和淋巴结转移均有密切关系(P<0.05),并且TopoⅡ和ki-67阳性表达具有较强的一致性。结论检测TopoⅡ和ki-67的表达可作为判断食管鳞癌预后的重要指标。Objective To discuss the expression of Topo II and Ki - 67 in esophageal sqauamous cell carcinoma and their relationship with the histodifferentiation grades and lymph node metastasis. Methods Immunohistochemistry was applied to study the expression. Results Topo Ⅱ and Ki - 67 were closely related to the histodifferentiation grades and lymph node metastasis of esophageal squamous cell carcinoma , and there existed a great consistence between the positive expression of Topo Ⅱ and Ki - 67. Conclusions The expression of Topo Ⅱ and Ki - 67 can be used as the important index in judging the prognosis of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 Top0Ⅱ KI-67 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]