不同组织类型和分化程度膀胱肿瘤组织c-met的表达差异  

The Expression of C-met in Bladder Cancers of Different Differentiation and Histological Types

作　　者：甘文[1] 潘卫兵[1] 李美红[1] 杨海魁[1] 潘锦贤 

机构地区：[1]广东省深圳市坪山人民医院泌尿外科,广东深圳518118

出　　处：《广州医学院学报》2008年第2期29-31,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨不同分化程度和组织学类型的膀胱肿瘤组织c-met表达水平的差异。方法:免疫组织化学法测定33例不同分化程度和组织学类型的膀胱肿瘤组织中c-met的表达水平。结果:移行上皮细胞癌、鳞癌和腺癌组阳性率分别为80.0%、42.8%、33.3%,移行细胞癌组织c-met的表达明显高于鳞癌和腺癌(P<0.05);高分化、中分化和低分化组患者阳性率分别为66.7%、53.8%、72.7%,高、中、低不同分化组中c-met的表达水平无明显差异(P>0.05)。结论:c-met在移行上皮细胞癌膀胱癌患者组织表达明显增高,但与肿瘤分化程度无关。Objective： To explore the difference in expression levels of c- met in the bladder cancers with different differentiation and histological types. Methods： The c- met expression in 33 patients was detected by immunohistochemistry. Results： The expression of c-met was positive in 80.0% of transitional cell carcinomas, 42.8% of squamous cell cancers and 33.3% of adenocarcinomas respectively, as well as in 66.7% of well-differentiated, 53.8% of moderately differentiated and 72.7% of poorly differentiated cancers, respectively. There was no difference in c-met expression across cancers with varied degrees of differentiation （P〉O.05）. Conclusion： The expression of c- met appeared higher in transitional cell carcinomas than in squamous cell cancers or adenoearcinomas, but not related with degree of cell differentiation.

关 键 词：膀胱肿瘤 C-MET 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]