TRPM8的研究进展  

The progress in TRPM8 research

作　　者：杜晶[1] 张励才[1] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室,江苏徐州221002

出　　处：《中国药理学通报》2008年第9期1135-1138,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30570974)

摘　　要：TRP(transient receptor potential)离子通道是一类广泛存在于细胞膜上的跨膜蛋白质,可以辨别酸甜苦辣等各种味觉和温暖、冷、热等各种温度觉。TRP通道亚型TRPM8最初作为一种前列腺特异性蛋白被克隆出来,并可在热敏反应中被冷刺激和薄荷醇激活。TRPM8可以感知温度觉和痛觉,并可缓解疼痛,具有重要的研究意义。该文拟就当前TR-PM8的生物物理学、门控机制和这类TRP通道的药理及病理生理机制等进行综述。TRP （transient receptor potential） ion channel is a kind of membrane proteins which are widespreadly present in various cells, which is used to identify various mixed flavor and warm,heat, cold, and other temperature. Originally cloned as a proatate-specific protein. TRPM8 is now best known as a coldand menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and （patho） physiology of this TRP channel .

关 键 词：TRPM8 温度觉 门控机制 肿瘤 

分 类 号：R-05[医药卫生] R329.25