苦参素联合驱铜治疗对肝豆状核变性患者肝纤维化血清学指标的影响  

Effect on index of hepatic fibrosis in serumology by combined use of kushenin and decopper therapy in treating hepatolenticular degeneration

作　　者：胡文彬[1] 吴舒梅[2] 薛本春[1] 苏增锋[1] 杨金鹏[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所附属医院,安徽合肥230061 [2]安徽省巢湖市第二人民医院神经内科,安徽合肥238000

出　　处：《安徽医药》2008年第11期1071-1072,共2页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省自然科学基金项目(050430803);安徽省教育厅自然科学研究项目(2006KJ070C)

摘　　要：目的探讨苦参素联合二巯基丙磺酸(DMPS)驱铜治疗对肝豆状核变性(HLD)患者肝纤维化血清生化指标的影响。方法HLD患者61例随机分为苦参素联合DMPS组31例和DMPS组30例,两组的其他基础治疗相同。DMPS组患者仅使用DMPS驱铜治疗2个月;苦参素联合DMPS组患者同时使用苦参素静脉滴注2个月。检测上述两组患者疗程前后肝纤维化血清生化指标的变化。结果疗程后苦参素联合DMPS组血清肝纤维化指标透明质酸(HA)、层粘蛋白(LN)、IV型胶原(Ⅳ-C)均显著减低(P<0.01),HLD患者的肝纤维化血清学指标明显改善;而DMPS组无显著变化。结论苦参素联合驱铜治疗可使HLD患者的肝纤维化程度在短期内获得明显改善。Aim To explore the effect on the index of hepatic fibrosis in serumology by combined use of kushenin and decopper therapy in treating hepatolenticular degeneration （HLD）. Methods 61 HLD patients were randomly divided into 2 groups：31 in DMPS combined kushenin group and 30 in DMPS group. The two groups received the same basic treatment. The DMPS group was given DMPS de-copper for two months,while the DMPS combined kushenin group was given the above-mentioned treatment and meanwhile intravenous drip of kushenin for two months. Changes of the index in serumology pretherapy and post-treatment were observed. Results After the course of treatment ,the index of hepatic fibrosis （ HA, LN,Ⅳ- C ） in DMPS combined kushenin group were markedly decreased（ P 〈 0.01 ）. The index of hepatic fibrosis in serumology were significantly ameliorated and.that in DMPS group didn＇t markedly change. Conclusion Combined use of kushenin and de-copper therapy effective decrease the degree of HLD patients＇ hepatic fibrosis in short-term treatment.

关 键 词：苦参素 驱铜治疗 肝纤维化 血清学指标 肝豆状核变性 

分 类 号：R742.4[医药卫生—神经病学与精神病学] R575.24[医药卫生—临床医学]