胆汁酸对糖脂代谢影响的研究现状  

Effect of bile acids on glucose and lipid metabolism

作　　者：孙逊[1] 杨刚毅[1] 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010

出　　处：《国际内分泌代谢杂志》2008年第5期323-325,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30771037）;国家教委春晖计划资助项目（2003-56）;重庆市教委科研基金资助项目（JK050304）

摘　　要：胆汁酸是胆汁的重要成分，主要在肝脏合成，在膳食脂肪的消化吸收和胆固醇的代谢调节中发挥重要作用。近年来研究发现，胆汁酸还可激活法尼酯X受体-α、TGR5等信号分子，通过多种信号途径反馈调节自身的肠肝循环，同时还有降低血浆高密度脂蛋白和甘油三酯的作用，并且还参与糖代谢的调节，与体内糖脂代谢的动态平衡密切相关。因此，一些胆汁酸相关的信号途径很有希望成为治疗代谢性疾病的新靶点。Bile acids, synthesized in liver,is a primary component of bile. It plays an important role in the digestion and absorption of dietary lipid as well as in cholesterol homeostasis. Recently, many studies showed that bile acids could activate several signaling molecules, such as farnesoid X receptor α and TGRS. Through these mechanisms, bile acids regulates its entero-hepatic circulation, brings down plasma levels of high density lipoprotein, triglyceride and regulates glucose metabolism. So it is closely related to glucose and lipid homeostasis. Thus, several bile acids-related pathways are promising targets of metabolic disease therapy.

关 键 词：胆汁酸 FXR—α TGR5 糖脂代谢 

分 类 号：R[医药卫生]