基质金属蛋白酶-7及其组织抑制因子-1在胃癌中的表达与浸润、转移的关系研究  

Expression of Matrix Metalloproteinase-7 and Tissue Inhibitor of Metalloproteinase-1 in Gastric Carcinoma:Exploration Mechanism of Invasion and Metastasis

作　　者：孙淑明[1] 卢晓峰[1] 吴丽娥[1] 林小红[1] 林豪雨[1] 

机构地区：[1]汕头大学医学院第一附属医院外六科,广东汕头515041

出　　处：《汕头大学医学院学报》2008年第3期140-142,F0003,共4页Journal of Shantou University Medical College

基　　金：广东省医学科研课题资助项目(A2006438)

摘　　要：目的:探讨基质金属蛋白酶-7(MMP-7)及其组织抑制因子-1(TIMP-1)在胃癌中的表达与浸润、转移的关系。方法:应用免疫组化检测36例胃癌标本中肿瘤组织及癌旁组织中MMP-7和TIMP-1的表达,并进行回顾性随访。结果:胃癌组织中MMP-7阳性表达率(58.3%)明显高于癌旁组织(5.6%,P<0.01),胃癌组织中TIMP-1阳性表达率(44.4%)与癌旁组织(50.0%)无统计学意义。胃癌中MMP-7和TIMP-1之间表达强度关系无明显相关性。TIMP-1表达随胃癌TNM分期增加而减少(P<0.05)。结论:MMP-7表达与胃癌组织学行为有关,TIMP-1可能抑制胃癌的浸润、转移。Objective： To investigate the expression of matrix metalloproteinase-7（MMP-7）and tissue inhibitor of metalloproteinase-1（TIMP-1） in gastric carcinoma and their relationship with tumor cell invasion and metastasis. Methods： The immunohistochemistry was used to detect the expression of MMP-7 and TIMP-1 in 36 patients with gastric carcinoma. Results： The positive expression rate of MMP-7（58.3% ）in gastric carcinoma was higher than that of paracarcinoma mucesa（5.6%） （P 〈 0.05）, there was no difference of the expression of TIMP-1 between gastric cancer（44.4%）and paracarcinoma mucosa（50.0%）. The expression of TIMP-1 decreased with the increase of TNM staging（P 〈 0.05）. Conclusion： The expression of MMP-7 is related to the behavior of gastric carcinoma, and the expression of TIMP-1 probably inhibits tumor cell metastasis.

关 键 词：胃癌 基质金属蛋白酶-7 基质金属蛋白酶抑制因子-1 

分 类 号：R735.2[医药卫生—肿瘤]