claudin-1、claudin-4在子宫内膜癌的表达及其意义  

Expression of claudin-1 and claudin-4 in endometrial carcinomas and its significance

作　　者：牛多山[1] 葛霞[1] 

机构地区：[1]蚌埠医学院病理学教研室,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2008年第5期515-517,F0004,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨claudin-1、claudin-4在子宫内膜癌的表达及其子宫内膜癌与临床病理参数之间关系。方法:采用免疫组化S-P法检测claudin-1、claudin-4在52例子宫内膜癌、24例子宫内膜非典型增生及19例增生期子宫内膜的表达,并与病理参数作相关分析。结果:在增生期子宫内膜、子宫内膜非典型增生、子宫内膜癌中,claudin-1阳性表达率分别为89.5%、66.7%、63.5%,呈下降趋势,差异具有统计学意义(P<0.005);claudin-4阳性表达率分别为36.8%、70.8%、90.4%,呈增高趋势,差异具有统计学意义(P<0.005)。claudin-1表达与癌组织分级、病理分期、肌层浸润深度、有否淋巴结转移及组织学类型均无关;claudin-4表达与癌组织肌层浸润深度有关,与以上其他病理参数无关。结论:claudin-1低表达、claudin-4高表达可能对子宫内膜癌发生、发展具有促进作用,两者在子宫内膜癌诊断、治疗和预后等方面具有潜在的应用价值。Objective：To explore the relations between the expression of claudin-1 and claudin4 in endomentrial carcinoma and the clinicopathologic parameters. Methods： The expressions of claudin-1 and claudin-4 were determined in 52 cases of endometrial carcinomas ,24 cases of dysplasias and 19 cases of proliferative endometriums by S-P immunohistochemistry, and their correlations to the clinicopathologic parameters were analyzed. Results ：The positive expression rates of claudin-1 in proliferative endometrium,endometrial dysplasia and endometrial carcinoma were 89.5% ,66.7% and 63.5% , respectively, with a trend of decreasing. The difference was significant in the three groups（P 〈0. 005 ）. The positive expression rates of claudin-4 in the above groups were 36.8% ,70.8% and 90.4% respectively,with a trend of increasing. There difference was significant in the three groups （P 〈 0. 005 ）. The expression of claudin-1 had no correlation to the histological grade, pathologic stage, myometrial invasion, lymph node metastasis or histological type; while the expression of claudin4 was related to the myometrial invasion, but had no relation to the above parameters. Conclusions： Hypoexpression of claudin-1 and overexpression of claudin-4 may be involved in the carcinogenesis and development of endometrial carcinoma,and may contribute to the diagnosis,treatment and prognosis of endometrial carcinoma.

关 键 词：子宫肿瘤 子宫内膜癌 CLAUDIN-1 CLAUDIN-4 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]