细胞动力学研究进展与展望  

Progress and perspective of cellular dynamics studies

作　　者：姚雪彪[1] 

机构地区：[1]中国科技大学生命科学学院,安徽合肥230027

出　　处：《中国科学技术大学学报》2008年第8期878-882,共5页JUSTC

基　　金：国家重点基础研究发展(973)计划(2002CB713700);国家自然科学基金(39925018);中国科学院知识创新工程(KSCX2-2-01)资助

摘　　要：细胞是生命活动的最小单元,其功能可塑性及动力学特征是维系生命个体健康及物种繁衍的重要保证.在分子水平,细胞可塑性与动力学特征受遗传学及表观遗传学的调控.随着基因组计划的顺利完成及我们对细胞增殖重要蛋白质作用网络生物化学特征研究的成功实施,揭示细胞重要生命活动过程中功能分子的动力学特征及其调控机制显得日益重要.组建中国科学技术大学细胞动力学实验室旨在纳米尺度揭示细胞重要生命活动全过程的详尽全息分子调控机制.在过去的几年中,已取得了动点蛋白质网络研究的阶段性进展,在动点蛋白复合物组分剖析、功能评估、蛋白质作用动力学及可塑性研究等方面均取得了具有特色的成绩.目前,拟在纳米尺度评估动点组装的时空动力学调控机制.相信在未来的日子里,细胞动力学实验室的创新性成果能够综合集成,并为人口与健康领域的重大命题提供相关的解答方案与技术平台.The cell is a fundamental building block of life. Cellular dynamics and plasticity are essential for animal development, growth and reproduction. At the molecular level, cellular plasticity and dynamics are governed by genetic and epigenetic regulations. With the completion of animal genomes and elucidation biochemical characterization of macromolecule interactions, it is becoming increasingly important to delineate the spatiotemporal dynamics and regulation of key regulators underlying cellular dynamics such as cell division, which was the chief objective to build the Laboratory of Cellular Dynamics in the University of Science and Technology of China at the beginning of this Millennium. Using kinetochore assembly in mitosis as a model system, the Laboratory of Cellular Dynamics has successfully carried out molecular dissection of mammalian kinetochore composition, elucidated several important kinetochore interacting networks and illustrated the key regulator dynamics. Toward the completion of molecular delineation of mammalian kinetochore interactome and signaling cascades, the Lab aims to illuminate the molecular dynamics underlying kinetochore assembly at nano scale. Successful accomplishment of their long-term objectives will enable us to consolidate dynamic protein-protein interactome into nano-scale physiology, which will provide a launch-pad for solving complex biological questions such as stem cell plasticity and for designing better anti-cancer drugs.

关 键 词：基因组 基因组稳定性 细胞动力学 细胞分裂 细胞可塑性 动点 蛋白质作用网络 

分 类 号：Q291[生物学—细胞生物学]