非小细胞肺癌组织中hnRNP B_1和CD44的联合表达及其与预后的关系  

Co-expression and Prognostic Significance of hnRNP B_1 and CD44 in Non-small Cell Lung Cancers

作　　者：邓太兵[1] 李为民[1] 莫显明[2] 刘伦旭[3] 刘丹[1] 蒲蓉[1] 陈勃江[1] 徐炼[4] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041 [2]四川大学华西医院生物治疗国家重点实验室 [3]四川大学华西医院胸外科 [4]四川大学华西第二医院病理科

出　　处：《四川大学学报（医学版）》2008年第5期819-822,共4页Journal of Sichuan University(Medical Sciences)

基　　金：教育部博士点基金(批准号20050610056)资助

摘　　要：目的研究核内不均一核糖核蛋白B1(hnRNP B1)和CD44在非小细胞肺癌组织中的联合表达及其与预后的关系。方法应用免疫组织化学的方法检测88例非小细胞肺癌组织中hnRNP B1和CD44表达,分析hnRNP B1和CD44的联合表达与肺癌预后的关系。结果非小细胞肺癌组织中hnRNP B1和CD44的高表达率分别为68.18%和52.27%。hnRNP B1高表达且CD44低表达组,平均生存时间最高(59.607±4.092)月;hnRNP B1低表达且CD44高表达组,平均生存时间最低(21.357±3.545)月,差异具有统计学意义(P<0.05)。结论hnRNP B1与CD44联合检测对判断非小细胞肺癌的预后有一定临床意义。Objective To study the co-expression and prognostic signlfieance of hnRNP B1 and CD44 in non-small cell lung cancers （NSCLC）. Methods The co-expressions of CD44 and hnRNP B1 in the tissues from 88 cases of NSCLC were measured by immunohistochemistry. The relationship between the expressions and the prognosis of NSCLC was analysed. Results The NSCLC had a high expression of hnRNP B1（68.18%） and CD44 （52.27%）. The cells had the longest average life （（59. 607±4. 092） months] in the conditions of high expressed hnRNP Bl and low expressed CD44, and shortest average llfe （（21. 357±3. 545） months] in the conditions of low expressed hnRNP B1 and high expressed CD44. Conclusion Combined detection of hnRNP ]31 and CD44 can help forecast the prognosis of NSCLC.

关 键 词：CD44 核内不均一核糖核蛋白B1 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]