亚硝酸钠对泥鳅红细胞的遗传损伤研究  

Study on the Genetic Damage to Red Blood Cell of Loach by NaNO_2

作　　者：陈鲤群[1] 陈娜娜[1] 连丽丽[1] 许美轮[1] 吴若菁[1] 

机构地区：[1]福建师范大学生命科学学院,福州350108

出　　处：《海峡预防医学杂志》2008年第4期11-13,共3页Strait Journal of Preventive Medicine

基　　金：福建省科技厅重点项目(项目编号:2007N0042);福州市科技局重点项目(项目编号:2006-Z-39)

摘　　要：[目的]研究亚硝酸钠在不同浓度和不同染毒时间对泥鳅红细胞的损害,观察改性竹炭-K对亚硝酸钠的吸附效果。[方法]用微核率评价亚硝酸钠对泥鳅的红细胞遗传损伤。[结果]亚硝酸钠的损害主要表现在微核率以及核变形率的增高,且在一定浓度范围内,随着浓度的升高和染毒时间的延长而越来越高。用改性竹炭-K对400mg/L的亚硝酸钠吸附处理,效果显著。[结论]亚硝酸钠对泥鳅的LD50为272mg/L;对泥鳅的遗传损伤表现为微核率和核变形率增高;改性竹炭-K对亚硝酸钠的吸附作用显著。[Objective] To study the genetic damage to red blood cell of loach by differenl concentrations and exposure time of NANO2, and observe the absorption effect of modified bamboo charcoal-K. [Methods] Micro-nuclear rate was used to evaluate the genetic damage to red blood cell of loach by NANO2,, [-Results] The main genelic damage by NaNO2 showed the increased rates of micro nuclear and nuclear deformation. And at a certain concentration ranges, the micro-nuclear rate increased significantly with the increasing of concentration and exposure time of NaNO2. Modified bamboo charcoal-K existed obvious adsorption function at 400 mg/L concentration. [Conclusion] The LD50 of NaNO2to loach is 272 mg/L;The main genetic damage by NANO2, shows the increased rates of micro-nuclear and nuclear deformation. And modified bamboo charcoal-K shows good adsorption function to NaNO2.

关 键 词：亚硝酸钠 泥鳅 红细胞 遗传损伤 改性竹炭-K 

分 类 号：R994.4[医药卫生—毒理学]