内皮祖细胞与缺血性脑血管病的细胞治疗  

Endothelial Progenitor Cells and Cell Therapy of Ischemic Cerebrovascular Disease

作　　者：鲁友明[1] 邓志锋[1] 汪泱[2] 

机构地区：[1]南昌大学第二附属神经外科,330006 [2]南昌大学第一附属医院泌尿外科研究所,330006

出　　处：《国际脑血管病杂志》2008年第8期595-599,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金资助项目（No.30560156）

摘　　要：内皮祖细胞（EPC）是血管内皮细胞的前体细胞，存在于骨髓、外周血和脐血中，并参与出生后的血管发生过程。内源性和外源性因素刺激可动员骨髓EPC进入外周血，参与缺血组织的血管重建和损伤血管的再内皮化过程。血液循环中的EPC数量或质量下降是缺血性卒中预后不良的重要原因之一。EPC移植有可能为缺血性脑血管病的治疗提供一种全新的治疗策略。Endothelial progenitor cells （EPCs） are the precursor cells of vascular endothelial cells. EPCs are in bone marrow, peripheral blood and cord blood. They participate in the process of angiogenesis after birth. The stimulation of exogenous and endogenous factors mobilizes bone marrow-derived EPCs into peripheral blood, and participates in the revascularization of ischemic tissue and the process of re-endothelialization of the injured blood vessels. The decreased numbers and quality of EPCs in blood circulation are one of the most important factors of unfavourable prognosis after ischemic stroke. The transplantation of EPCs may provide a novel therapeutic strategy for the treatment of ischemic cerebrovascular disease.

关 键 词：内皮祖细胞 缺血性脑血管病 血管发生 

分 类 号：R743.3[医药卫生—神经病学与精神病学]