颈动脉狭窄患者认知功能损害的临床特征研究  

Clinical study of cognitive impairment in patients with carotid artery stenosis

作　　者：刘勇[1] 郑健[1] 李玲[1] 李黔宁[1] 帅杰[1] 卢丽[1] 王进平[1] 

机构地区：[1]第三军医大学新桥医院神经内科,重庆400037

出　　处：《重庆医学》2008年第18期2030-2032,共3页Chongqing medicine

摘　　要：目的了解颈动脉狭窄患者认知功能损害的临床特征,促进颈动脉狭窄患者认知功能损害临床诊治水平的提高。方法采用威斯康星卡片分类测验、词语流畅性测验和连线测验等神经心理学量表,对经全脑血管造影证实的31例症状性颈动脉狭窄或闭塞患者(狭窄组)和14例无颈动脉狭窄患者(无狭窄组)进行认知功能评价。结果狭窄组和无狭窄组持续反应数(Rp)、词语流畅性测验(VFT)和符号-数学模式测验(SDMT)结果差异有统计学意义(P<0.05);颈动脉中、重度狭窄患者Rp、VFT、美国国立卫生院神经功能缺损评分和工具性日常生活活动能力,测评结果差异有统计学意义(P<0.05)。结论颈动脉狭窄患者存在认知损害,以认知转换、执行功能和注意功能损害表现突出。Objective To investigate the clinical features of cognitive impairment in patients with carotid artery stenosis. Methods Thirty-one patients with symptomatic carotid artery stenosis or occlusion（stenosis）and 14 patients without carotid and intracranial vascular stenosis or occlusion（no-stenosis） identified by cerebral angiography were tested with a set of neuropsycbological scales,including sisconsin card sorting test（WCST）,verbal fluency test （VFT）, trail making test（TMT）and so on. Results They both had significant differences in the scores of Rp,SDMT and VFT between the stenosis and no-stenosis groups and the scores of Rp,VFT,NIHSS and IADL between the moderate stenosis and severe stenosis patients（P〈0.05）. Conclusion Patients with carotid artery stenosis have definite cognitive impairment, prominently in cognitive conversion, executive function, and attention.

关 键 词：颈动脉狭窄 脑血管病 认知 执行功能 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.5[医药卫生—临床医学]