再障红细胞的膜化学组成改变与代谢障碍机理  

Possible Mechanism Responsible for Changes of Membrane Chemical Composition and Metabolic Disorders in Erythrocytes Suffered from Aplastic Anemia

作　　者：刘斯奇[1] 唐建华[1] 史建健[1] 李虹[1] 周玉球[1] 彭岚[1] 刘立鹏[1] 雷厉[1] 徐金耀[1] 刘俊凡[1] 卢义钦[1] 

机构地区：[1]中南大学湘雅医学院生物科学与技术学院生物化学系再障红细胞研究组

出　　处：《生命科学研究》2008年第3期193-199,共7页Life Science Research

基　　金：中华医学基金会(CMB)资助项目(900105);国家自然科学基金资助项目(39670908)

摘　　要：再生障碍性贫血(AA)严重危害人类健康.为阐明患者造血干细胞与骨髓微环境受损的病理生化机理,多年来从多条途径进行了探索.1986～2001年,研究组从临床生化与实验血液学的角度,较系统地研究了AA患者与AA大、小鼠模型红细胞的膜化学组成攺变与代谢障碍.现就所获结果扼要作一综述.Aplastic anemia （AA） is severely harmful to the health of mankind. In order to elucidate the pathobiochemical mechanism involved in the damage of hematopoietie stem cells and myeloid microenvironment in AA patients, multiple routes of investigation were approached for several decades. From the standpoint of clinical biochemistry and experimental hematology, within 15 years （1986-2001） the changes of membrane chemical composition and metabolic disorders in erythrocytes of AA patients and some rodent models with AA were studied. Here the results obtained are briefly reviewed.

关 键 词：再生障碍性贫血(再障) 红细胞与红细胞膜 代谢障碍 

分 类 号：Q592.1[生物学—生物化学] R556.5[医药卫生—血液循环系统疾病]