结直肠癌患者TuM2-PK表达水平及其临床意义  

Expression and clinical significance of tumor M2 pyruvate kinase in colorectal cancer patients

作　　者：陈连周[1] 何裕隆[1] 吴耀良[2] 王东[2] 汪谦[1] 

机构地区：[1]中山大学附属第一医院外科,广州510080 [2]中山大学附属第一医院检验科,广州510080

出　　处：《中国卫生检验杂志》2008年第9期1830-1831,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨结直肠癌患者粪便中肿瘤型M2丙酮酸激酶(TuM2-PK)表达水平及其临床意义。方法:用酶联免疫吸附法(ELISA)检测56例结直肠癌患者,36例肠道息肉患者,50例正常对照的粪便中的TuM2-PK水平。结果:结直肠癌组粪便TuM2-PK水平/阳性率(10.2U/ml/75.0%)明显高于肠道息肉组(1.5U/ml/5.6%)和健康对照组(0.9U/ml/6.0%)(P<0.01)。TuM2-PK诊断结直肠癌的敏感度为75.0%,特异度为94.1%。结论:粪便TuM2-PK检测对结直肠癌诊断具有一定的临床意义。Objective：To investigate the expression and clinical significance of fecal tumor M2-PK in colorectal cancer patients.Methods：The levels of fecal tumor M2-PK was detected by ELISA in 50 healthy controls,36 colorectal polyp patients and 56 colorectal cancer patients.Results：Fecal TuM2-PK levels and positive rate was singificantly higher in colorectal cancer（10.2U/ml,75.0%） than that of in colorectal polyp and in health controls（1.5U/ml,5.6% and 0.9U/ml,6.0%）（P〈0.01,respectively）.The diagnostic sensitivity and specificity was 75.0% and 94.1%,respectively.Conclusion：Fecal TuM2-PK can be used as a valuable diagnostic marker in colorectal cancer.

关 键 词：丙酮酸激酶 结直肠肿瘤 诊断 

分 类 号：R735.37[医药卫生—肿瘤]