葡萄籽提取物和大豆磷脂混合制剂对老龄大鼠的抗氧化作用  

Effects of compounds of soybean phospholipid and extract of grape seed on antioxidative functions of old rats

作　　者：王亚东[1] 李立[1] 王海玉[1] 张聪恪[1] 张焱[1] 张桂霞[1] 刘翠娥[1] 

机构地区：[1]河南省疾病预防控制中心检验检测中心毒理室,郑州450016

出　　处：《中国卫生检验杂志》2008年第9期1887-1888,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨葡萄籽提取物和大豆磷脂混合制剂对老龄大鼠的抗氧化作用。方法:将48只雄性老龄大鼠按血清丙二醛水平随机分为低剂量组、中剂量组、高剂量组和老龄对照组,连续灌胃60 d后,测定血清中丙二醛(MDA)含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性。结果:与老龄对照组比较,高剂量组可使血清MDA含量显著降低;中剂量组和高剂量组显著升高血清SOD活性;GSH-Px活性无明显变化。结论:葡萄籽提取物和大豆磷脂混合制剂具有抗氧化功能。Objective：To study the effects of compounds of soybean phospholipid and extract of grape seed on antioxidative functions of old rats.Methods：48 old male rats were divided into low dose group,medium dose group,high dose group and old control group at random according to MDA content in serum.MDA content,SOD and GSH-Px activities in serum were determined after giving test substances by intragastrical gavage for 60 days.Results：MDA content in high dose group decreased significantly,SOD activities in medium and high dose group increased significantly by comparing with old control group;GSH-Px activities were not different among the four groups.Conclusion：Compounds of soybean phospholipid and extracts of grape seed have effects on antioxidation of old rats.

关 键 词：葡萄籽 大豆磷脂 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 

分 类 号：R114[医药卫生—卫生毒理学]