肠癌患者手术治疗前后血清VEGF和SE-CAD水平检测的临床意义  

Clinical Significance of Changes of Serum VEGF and SE-CAD Levels After Operation in Patients with Colorectal Cancer

作　　者：孙志勇[1] 孙巍[1] 方立俭[1] 秦继宝[1] 汤其岭[1] 

机构地区：[1]江苏省连云港市第一人民医院东方医院,江苏连云港222042

出　　处：《标记免疫分析与临床》2008年第4期196-197,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：为了探讨肠癌患者手术治疗前后血清VEGF、SE-CAD水平的变化及意义,本文应用ELISA法对41例肠癌患者手术治疗前后血清VEGF和SE-CAD水平进行测定,并与35名健康人(对照组)作比较。结果表明肠癌患者手术治疗前血清VEGF、SE-CAD水平均非常显著地高于对照组(P<0.01),手术治疗后半年,复发组血清VEGF、SE-CAD水平又明显高于未复发组(P<0.01)。肠癌患者手术治疗前后血清VEGF、SE-CAD水平变化与患者的病情和预后密切相关,具有一定的临床价值。To explore the clinical significance of changes of serum VEGF and SE-CAD levels after operation in patients with colorectal cancer,the serum VEGF and SE-CAD levels were determined by ELISA in 41 patients with colorectal cancer before and after operation and in 35 healthy controls.The results showed that the serum VEGF and SE-CAD levels in patients before operation were significantly higher than those in controls（P〈0.01）.36 of the 40 patients underwent operation showed no sign of recurrence after 6 months and their serum VEGF and SE-CAD levels dropped to normal range.Other 4 patients recurred with higher serum VEGF and SE-CAD levels compared with those without recurrence（P〈0.01）.The serum VEGF and SE-CAD levels of patients with colorectal cancer are closely related to the process and prognosis of diseases.

关 键 词：肠癌 血管内皮生长因子 可溶性上皮钙蛋白 

分 类 号：R735.3[医药卫生—肿瘤]