可溶性主要组织相容性复合体Ⅰ类相关分子A与肺癌的相关性  

Research on relevance of sMICA and lung cancer

作　　者：梁晶[1] 韩福才[2] 乔丽娟[3] 单彬彬[2] 

机构地区：[1]山西医科大学第二医院,太原030001 [2]山西省肿瘤医院呼吸内科 [3]山西省肿瘤医院免疫室

出　　处：《肿瘤研究与临床》2008年第9期600-603,共4页Cancer Research and Clinic

摘　　要：目的探讨可溶性主要组织相容性复合体I类相关分子A（sMICA）对肺癌诊断的临床参考价值，评价肺癌患者血清sMICA表达水平与肿瘤生物学之间的相关性。方法采用酶联免疫吸附法对116例肺癌患者血清sMICA进行检测，并对其中的91例初治患者血清CEA、NSE、CA～199、CYFRA-211、SCC、ProGRP进行检测，与50名健康人血清sMICA作对照。结果肺癌患者血清sMICA显著高于健康人（P〈0．001）；sMICA作为肺癌诊断的-项指标，以240．5ng／L作为截点，其敏感度为90．1％，特异度为46．9％，与上述6项血清肿瘤标志物相比较，阳性检测率较高（P〈0．001）；治疗有效的肺癌患者化疗后sMICA水平下降（P〈0．05），复发转移肺癌患者血清sMICA与初诊患者比较显著升高（P〈0．001）。结论sMICA可作为-项新的肺癌肿瘤标志物，其敏感度、特异度均较高，单项阳性检出率均优于其他6种肿瘤标志物，且sMICA与肺癌的进展、转移有关，监测sMICA有助于观察疗效，评估预后。Objectives To study the clinical diagnostic value of soluble major histocompatibility complex class I -related chain A（sMICA ） and analyse the relationship of tumor biologic characteristics and sMICA in lung cancer. Methods The experimental level of sMICA was determined by ELISA in 116 lung cancer patients. The level of serum CEA, NSE, CA-199, CYFRA-211, SCC, ProGRP were determined by ELISA only in 91 lung cancer patients without any therapy. The level of sMICA in 50 normal persons was regarded as control group. Results The level of sMICA in lung cancer patients was significantly higher than that in control group （P 〈0.001）; When sMICA cut-off was set as 240.5 ng/L, the sensitivity for the detection of lung cancer was 90.1%, the speciality was 46.9 %. The positive rate of sMICA was significantly higher than that of CEA, NSE, CA-199, CYFRA-211, SCC, ProGRP（P 〈0.001 respectively）; The level of sMICA in lung cancer patients with CR and PR after treatment were lower than that before treatment（P 〈0.05）. The level of sMICA in lung cancer patients with relapse was higher than patients without any treatment （P〈O.O01）. Conclusion SMICA may be a potential marker for diagnosing lung cancer with high sensitivity and speciality. It is associated with tumor progression and distant metastasis and may be helpful in the evaluation of diagnosis for lung cancer.

关 键 词：肺肿瘤 基因 MHCⅠ类 肿瘤标记 生物学 相关性 

分 类 号：R734[医药卫生—肿瘤]