凋亡抑制基因Survivin与肺癌的关系  

Research status in relationship between Survivin and lung cancer

作　　者：杨升(综述)[1] 卢辉山(审校)[1] 

机构地区：[1]福建医科大学附属协和医院肿瘤科,福州 350001

出　　处：《肿瘤研究与临床》2008年第9期641-643,共3页Cancer Research and Clinic

基　　金：福建省自然科学基金计划（2008J0284）

摘　　要：Survivin是属于凋亡抑制蛋白（1AP）家族中的新成员，具有抑制细胞凋亡和调节细胞分裂等功能。Survivin主要在胚胎发育组织表达，在成人终末分化组织低表达或不表达，而在绝大多数肿瘤组织中高表达。研究表明，Survivin与肺癌的发生、发展有着密切关系，因而可望成为肺癌新的诊断标志物及治疗靶点。Survivin is a recently identified member of the inhibitor of apoptosis protein （IAP） family which is a multifunctional protein with inhibition of apoptosis and regulation of cell division, and other functions. It is highly expressed in transformed cell lines and in a large number of malignancies, but undetectable in terminally differentiated adult tissues. Survivin play an important role in tumorigenesis of lung cancer. On the basis of these findings, Survivin will be of great interest as both a diagnostic tumor marker and as a potential suitable target for anti-lung cancer therapies.

关 键 词：肺肿瘤 凋亡抑制蛋白类 SURVIVIN 

分 类 号：R730.231.3[医药卫生—肿瘤]