蛋白酶激活受体-2在肿瘤细胞的表达及作用  

Expression and function of protease-activated receptor-2 on tumor cells

作　　者：石文霞(综述)[1] 周红(审校)[1] 

机构地区：[1]江苏大学基础医学与医学技术学院检验医学研究所,江苏镇江210001

出　　处：《肿瘤研究与临床》2008年第9期646-648,共3页Cancer Research and Clinic

基　　金：教育部回国人员科研启动基金（教外司[2003]406）

摘　　要：蛋白酶激活受体-2（PAR-2）属于与G蛋白相耦联的受体家族，其N-末端被蛋白酶裂解后形成新的N-末端。新N-末端能够结合、激活受体自身。最新资料表明，PAR-2可表达于某些肿瘤组织及培养细胞，与肿瘤细胞的增生、侵袭与转移及血管生成等密切相关。Protease-activated receptor-2 （PAR-2） belongs to the receptor family which is coupled with G-protein. The N-terminus of PAR-2 is cleaved by some proteases to generate a new N-terminus. The new N-terminus can interact with and activate the receptor itself. The update research reported that PAR-2 could be expressed on some cancers as well as tumor cell lines. There are some relationships between the PAR-2 expression and the behaviors of tumor cell, such as proliferation, angiogenesis, migration and invasion.

关 键 词：细胞系 肿瘤 受体 PAR-2 

分 类 号：R730.231.3[医药卫生—肿瘤]