急性脑血管疾病患者超敏C-反应蛋白测定的临床意义  

The relationship between highly sensitive C reactive protein and acute cerebrovascular disease

作　　者：林晓东[1] 赵丽[1] 王学敏[1] 王海英[1] 田小卫[1] 李福学[1] 

机构地区：[1]河北省秦皇岛市第二医院神经内科,066600

出　　处：《中国临床实用医学》2008年第9期52-53,共2页China Clinical Practical Medicine

摘　　要：目的探讨急性脑血管病患者血清超敏C-反应蛋白（hs—CRP）水平的变化及其与疾病严重程度的关系。方法测定120例急性脑梗死、130例脑出血患者和90名健康人血清hs-CRP的含量，按脑卒中患者临床神经功能缺损程度评分标准对患者进行评分，分组比较。结果血清CRP水平脑梗死组、脑出血组明显高于正常对照组（P〈0．001），脑梗死组与脑出血组比较无差异（P〉0．05）。无论脑梗死组还是脑出血组，组内比较轻、中、重型患者血清hs-CRP水平差异均有统计学意义（P〈0．05）。结论血清hs—CRP水平增高与脑血管病的发生和严重程度有密切关系。Objective To investigate the changes of the serum level of highly sensitive C-reactive pro- tein （hs-CRP） in patients with cerebrovascular disease and its relationship to the severity of disease. Methods The serum level of hs-CRP in 120 patients with acute infarction and 130 patients with acute hemorrhage and 90 healthy persons were determined. All the patients were scored by clinic neurological deficit scale （NDS） , and compared in groups. Results The serum level of hs-CRP in the patients were significantly higher than that in normal controls （P 〈 0. 001 ） and it were significantly higher in the serious group than in the middle and mild groups （ P 〈 0.05 ）. Conclusion The serum level of hs-CRP is closely correlated with the severity of cerebro- vascular disease.

关 键 词：动脉粥样硬化 脑梗死 脑出血 超敏C-反应蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]