细胞外基质力学性质对实体肿瘤血管生成影响的数值模拟  

Numerical Simulation on the Effect of Mechanical Properties of ECM on Tumor-induced Angiogenesis

作　　者：Gulnara Kalkabay 曹金凤[1] 蔡彦[1] 许世雄[1] 

机构地区：[1]复旦大学力学与工程科学系,上海200433

出　　处：《生物医学工程学进展》2008年第3期131-135,共5页Progress in Biomedical Engineering

基　　金：国家自然科学基金项目(10772751)(10372026);上海市重点学科建设项目(B112)

摘　　要：考虑细胞外基质ECM力学性质对实体肿瘤血管生成的影响,数值模拟肿瘤内外血管网络。将肿瘤外正常组织ECM和肿瘤组织ECM均设为线弹性体,考虑内皮细胞的扩散运动、对肿瘤血管生成因子TAF的趋化性响应、对粘连蛋白FN趋触性响应以及对流运动,进行数值模拟。计算结果表明模型能够获得较为真实的分层毛细血管网络。In this paper, we investigate the effect of mechanical properties of ECM on tumor- induced an- giogenesis and simulate the capillary network numerically. The ECM is assumed to be linear elastic. Diffusible movement, chemotactic response to TAF, haptactic response to FN, and convection are considered in the model. The calculation results a layered structure： at the edge of tumor, numerous capillaries are generated, while closer to the tumor center, less the capillary.

关 键 词：实体肿瘤 血管数值生成 细胞外基质 力学性质 

分 类 号：R73-3[医药卫生—肿瘤] R318.01[医药卫生—临床医学]