甲状腺乳头状癌NSE、CgA、Syn的表达及其临床意义  

Expression and significannce of NSE,Syn and CgA in thyroid papillary carcinoma

作　　者：何松[1] 陈旭东[1] 潘宏佳[1] 喻朝霞[2] 戴瑜珍 严桥[1] 

机构地区：[1]南通大学附属肿瘤医院病理科,226361 [2]安庆市第一人民医院病理科

出　　处：《江苏医药》2008年第9期882-884,F0002,共4页Jiangsu Medical Journal

基　　金：南通市社会发展科技计划(S5010)

摘　　要：目的探讨NSE、CgA、Syn与甲状腺乳头状癌临床病理和预后相关因素的关系。方法对103例甲状腺乳头状癌病例,用免疫组织化学法分别进行NSE、CgA、Syn标记,观察其与临床病理参数间的关系。结果103例甲状腺乳头状癌中,NSE、CgA和Syn阳性表达率分别为62.14%、24.27%和0%;NSE及CgA共同表达23例(22.33%)。甲状腺乳头状癌的病灶大小与NSE表达有关,癌细胞分化程度及核内包涵体与CgA表达有关(P<0.05)。结论甲状腺乳头状癌神经内分泌标记的表达与患者预后相关因素有关,并影响乳头状癌细胞核的特征性改变。Objective To study the expressions of NSE, Syn and CgA and their association with clinical pathology, prognostic correlation factors of thyroid papillary carcinoma. Methods One hundred and three thyroid papillary carcinomas were marked with NSE, Syn and CgA with immunohistochemistry. The relationship of the expressions of NSE, Syn and CgA with clinical pathological parameters was observed. Results The positive expression percentages of NSE, CgA, and Syn in 103 thyroid＇papillary carcinomas were 62.14%, 24.27% and 0%, respectively. Coexpression of NSE and CgA was seen in 23 cases（22.33%）. Expression of NSE was related with the size of tumor （P〈0. 05）, while expression of CgA was related to the differentiation degree of carcinoma cell and nuclear inclusion （P〈 0. 05）. Conclusion Thyroid papillary carcinoma with neuroendocrine differentiation tends to be associated with the prognostic correlation factors, and mhy influence the nuclear character.

关 键 词：甲状腺乳头状癌 神经内分泌分化 

分 类 号：R736[医药卫生—肿瘤]