白血病干细胞分子生物学特性及其治疗策略研究进展  

Molecular characteristics of leukemia stem cells and up-dating therapeutic strategy

作　　者：古莹[1] 邱曦[1] 徐荣臻[1] 

机构地区：[1]浙江大学医学院附属第二医院血液科,浙江杭州310009

出　　处：《基础医学与临床》2008年第9期904-907,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30672381)

摘　　要：耐药与复发是白血病治疗失败两大主要原因,但其病因与确切分子机制迄今不详。近年来,已有越来越多的研究表明,白血病患者体内除了含有大量幼稚白血病细胞外,还存在着一群比例极少的白血病干细胞(LSCs)。这些肿瘤性干细胞对目前常用的化疗药物无反应,被认为是白血病耐药和复发的主要根源,只有清除LSCs才有可能根治白血病。本文简要介绍白血病干细胞基本分子生物学特性及相应治疗策略研究进展。Drug resistance and relapse are two major causes for treatment failure of leukemia, but their mechanisms remain elusive. Recently, increasing evidence shows that there is a subset of leukemia stem cells apart from immature leukemia ceils in leukemia patients. These malignant stem ceils do not response to routine chemotherapeutic agents, and may be the source of drug resistance and relapse of leukemia. Permanent cure of leukemia need elimination of these leukemia stem cells. We describe molecular characteristics of leukemia stem cells and possible target therapeutic strategies in this review.

关 键 词：白血病干细胞 白血病复发 耐药 

分 类 号：R733.7[医药卫生—肿瘤]