厚朴酚对高脂饮食性肥胖大鼠体重及胰岛素抵抗的影响  

Effects of magonol on body weight and insulin resistance of fat-rich food-fed obese rats

作　　者：郭真[1] 袁良杰[1] 卢霞[1] 蔺美玲[1] 郑天珍[1] 李伟[1] 

机构地区：[1]兰州大学基础医学院生理学与心理学研究所

出　　处：《基础医学与临床》2008年第9期936-939,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30572428)

摘　　要：目的观察厚朴酚对高脂饮食性肥胖大鼠体重和血清生化指标的影响,并探讨其机制。方法将SD大鼠随机分成4组:对照组,高脂组和厚朴酚高、低二个剂量组。每天定时称量食水、灌胃,每周测体重,第8周末各组大鼠禁食12h后股动脉取血测定血清生化指标。结果低剂量厚朴酚组从第4周开始体重比高脂组显著降低(P<0.05),高、低剂量厚朴酚组的胰岛素、游离脂肪酸、丙二醛以及低剂量组的血糖、三酰甘油比高脂组都显著下降(P<0.05)。结论厚朴酚能降低高脂饮食性肥胖大鼠的体重,并对胰岛素抵抗和糖脂代谢紊乱等有一定的改善作用。Objective To study the effects of magnolol on body weight and insulin resistance of rat fed with fat rich food and to discuss the possible mechanism. Methods SD rats were randomized into 4 groups ： （ 1 ） normal control group fed with ordinary diet and administered normal saline, （2）fat-rich diet group administered normal saline,（3） and （4） groups fed with high fat diet and administered high and low concentration of aqueous suspension of magnolol diluted by normal saline respectively. Food intake was monitored daily and body weight was weighed weekly at the set time. At the end of the eighth week, All rats were fasted for 12 hours to collect blood for measuring biochemical Indexes, including glucose, insulin, free fatty acid （ FFA）, total antioxidative ability （ T-AOC ）, malondialdehyde （MDA） and so on. Results The body weight of rats in low dose group administered magnolol was lower than that of high-fat-fed group from the fourth week on （ P 〈 0. 05 ）. Compared with high-fat-fed group, the serum levels of insulin, FFA and MDA reduced in each group administered magnolol （ P 〈 0. 05 ）. Conclusion Magnolol can inhibit the weight gain caused by high-fat diet, reduce serum levels of MDA, FFA and insulin and improve the inlusin resistance and metabolic disorders.

关 键 词：厚朴酚 高脂饮食 肥胖 胰岛素抵抗 

分 类 号：R285.5[医药卫生—中药学]