膳食低钙对饲克山病区粮大鼠胰岛素分泌的影响  

EFFECT OF LOW Ca DIET ON INSULIN SECRETION IN RATS FED KESHAN DISEASE MONOTONOUS DIET

作　　者：郭成浩[1] 张辉[1] 张桂珍[2] 孙波[2] 赵志涛[2] 李广生[2] 王凡[2] 

机构地区：[1]青岛大学医学院中心实验室 [2]白求恩医科大学地方病研究所

出　　处：《中国地方病防治》1997年第5期258-260,共3页Chinese Journal of Control of Endemic Diseases

基　　金：国家"八五"攻关项目资助

摘　　要：本实验通过对模拟克山病偏食饲料中补充一定量的钙和硒来观察Wistar大鼠胰岛素(Ins)的变化。结果表明,病区粮组血钙水平最低,仅及常规食(stock)组一半;血清硒(Se),α-VE水平低于Stock组;Ins减少;血清过氧化脂质水平明显高于Stock组;血清GSH-Px活性低,有显著差异。补钙后钙水平升高,Se、α-VE水平变化不大;Ins显著升高。补Se/VE组Se、α-VE水平明显高于EM组。联合补Se/VE和Ca组Se、α-VE水平高于单纯补Se/VE组,有显著差异,Ins升高。补Se/VE、Ca各组可使过氧化脂质水平下降,有显著差异。综合分析结果表明,补Ca各组与EM组比较差异显著,表明膳食钙量对胰岛素影响极大。The effects of mimic Keshan disease endemic monotonous diet (EM diet)and that supplemented with Ca ,Se/VE on Insulin secretion in rats were studied. Wistar rats were composed of 5 subgroup by weight and sex. Results showed that EM diet was composed of corn chiefly and Ca content was low prominently as well as Se. The serum Ca,Se,VE levels and serum Insulin .GSH-Px activity in rats of EM group were significantly lower than those of the stock group rats. That LPO levels of myocardium and serum were significantly higher in EM group rats than those of stock group rats. When EM diet was supplemented Ca,serum Ca,Insulin were improved and Se,VE levels were no change. When EM diet was supplemented Se.VE,serum Se, VE. Insulin levels were markedly increased. LPO level decreased significantly in supplemented Ca,Se/VE groups. The study suggested that diet Ca play a role in Insulin secretion by systematic analysis.

关 键 词：膳食 低钙 硒 胰岛素 克山病 补钙 

分 类 号：R542.3[医药卫生—心血管疾病]