神经母细胞瘤骨髓转移23例临床病理分析  

Clinicopathological features of bone marrow metastasis of neuroblastoma

作　　者：王凤华[1] 张美德[1] 夏健清[1] 曾荣新[1] 

机构地区：[1]广州市儿童医院病理科,广州510120

出　　处：《临床与实验病理学杂志》2008年第4期395-398,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨神经母细胞瘤骨髓转移的临床病理特征。方法对23例神经母细胞瘤骨髓转移的临床病理资料进行分析,并做光镜观察及免疫组化染色。结果神经母细胞瘤骨髓转移表现为微小浸润、中度浸润和弥漫浸润三种形式,主要根据骨髓造血组织与肿瘤成分的比例和分布而定,其中微小浸润常需行CgA/NSE免疫组化染色辅助诊断。结论神经母细胞瘤骨髓转移的诊断需结合临床、光镜及免疫组化,以提高检出率并鉴别于横纹肌肉瘤、骨Ewing肉瘤、淋巴母细胞淋巴瘤/白血病。Purpose To study the elinicopathological features of bone marrow （BM） metastasis of neuroblastoma （NB）. Methods Twenty-three cases of neuroblastoma with bone marrow metastasis were reviewed and studied by light microscopy and immunohistoehemieal staining. Results There were three morphological types of BM metastasis of NB, microinvasive, moderately invasive and diffusely invasive pattern. CgA/NSE immunohistochemical staining was needed for confirming the metastatic neuroblastic cells in microinvasion. Conclusions It is important to combine clinicopathological characteristics with immunohistochemical results to obtain the highest yield of detection of metastasis and to differentiate it from rhabdomyosarcoma, Ewing＇ s sarcoma and lymphoblastic lymphoma/leukemia.

关 键 词：神经母细胞瘤 骨髓 转移 

分 类 号：R739.4[医药卫生—肿瘤]