儿童中枢神经系统肿瘤330例分析  

Central nervous system tumors in childhood:analyses of 330 cases

作　　者：桂婷[1] 张庆慧[1] 张廷国[1] 周志强[1] 刘文君[1] 李红[1] 王妍[1] 

机构地区：[1]山东大学齐鲁医院病理科,济南250012

出　　处：《临床与实验病理学杂志》2008年第4期403-406,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：山东省自然科学基金(2006GG2202010)

摘　　要：目的探讨儿童中枢神经系统（CNS）肿瘤的病理特征。方法按照2007年WHOCNS肿瘤分类标准,对山东大学齐鲁医院1995～2007年间16岁及其以下儿童颅内和椎管内肿瘤进行回顾性分析。结果儿童CNS肿瘤共330例,占同期全部4788例CNS肿瘤的6.89%。其中男性196例,女性134例。病理组织学类型前3位依次是：星形细胞瘤94例（28.48%）,胚胎性肿瘤58例（17.58%）和颅咽管瘤49例（14.85%）。299例颅内肿瘤中,幕上192例,幕下107例。椎管内31例。结论星形细胞瘤、胚胎性肿瘤和颅咽管瘤是最常见的儿童CNS肿瘤组织学类型。男性好发。随着年龄增长,CNS肿瘤有逐步上升的趋势。前十位CNS肿瘤中除胚胎性肿瘤和生殖细胞肿瘤外,均以低级别肿瘤多见。Purpose To study the pathological features of childhood central nervous system （CNS） tumors. Methods According to the 2007 WHO classification of the tumors of the nervous system, a retrospective analysis were performed on children （age≤ 16 years） diagnosed as CNS tumors in Qilu Hospital, Shandong University from 1995 to 2007. Results 330 cases （ 196 males and 134 females） were diagnosed as CNS tumors over 13 years. It accounted for 6. 89% of total 4,788 cases in our hospital during the same period. The top three histological types were： astrocytoma in 94 （28.48%）, embryonal tumors in 58 （17.58%） and craniopharyngioma in 49 （14. 85% ）. There were 299 cases of intracranial tumors, among which the supratentorial tumors were 192 cases and infratentorial tumors were 107 cases. There were 31 cases of intraspinal tumors. Conclusions Astrocytoma, embryonal tumors and craniopharyngioma are the most common types of CNS tumors in childhood. The incidence is male predominant. The incidence of CNS tumors is increasing with age. Most of the CNS tumors in the top of ten pediatric CNS tumors are the low grades （ grade Ⅰ or Ⅱ ） , except embryonal tumors and germ cell tumors.

关 键 词：中枢神经系统肿瘤 小儿 病理学 

分 类 号：R739.41[医药卫生—肿瘤]