Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer  

作　　者：Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen 

机构地区：[1]Department of Pathology, University of Turku, Kiinamyllynkatu 10, Turku FIN-20520, Finland Department of Pathology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya [2]Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1 PB 52, Turku FIN-20521, Finland [3]Department of Pathology, University of Turku, Kiinamyllynkatu 10, Turku FIN-20520, Finland

出　　处：《World Journal of Gastroenterology》2008年第31期4903-4908,共6页世界胃肠病学杂志（英文版）

基　　金：Partly the Special Government Funding (EVO)allocated to Turku University Central Hospital and CancerSociety of South-West Finland (Turku), No. 13687

摘　　要：AIM: To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. METHODS: Archival tumor samples were analyzed using immunohistochemistry (IHC) for α-catenin in 91 patients with advanced CRC. RESULTS: The values of α-catenin membrane index (MI) and cytoplasmic index (CI) were significantly related to the depth of tumor invasion (P = 0.027, P = 0.020, respectively), high indices being associated with increased depth of the primary tumor invasion (T3 and T4). Similarly, patients with high α-catenin expression had a signifi cantly increased risk of lymph node metastasis (32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI) (P = 0.001, P = 0.0001, respectively, for LNN status). An altered expression (i.e., cytoplasmic pattern) was also related (P = 0.047) to the response to chemotherapy; patients with low CI were more responsive (CR: 7/46) than patients with high CI values (CR: 0/45). There was a marginal effect on survival in patients time with metastases (SWM) (P = 0.087); patients with low CI showing slightly longerSWM, but no such effect on disease free survival (DFS) or disease specifi c survival (DSS). As to co-expression with another member of the adhesion complex (β-catenin), high α-catenin/β-catenin MI index was of marginal signifi cance in predicting longer DSS (P = 0.063, log-rank). CONCLUSION: The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC.AIM： To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer （CRC） patients. METHODS： Archival tumor samples were analyzed using immunohistochemistry （IHC） for α-catenin in 91 patients with advanced CRC. RESULTS： The values of α-catenin membrane index （MI） and cytoplasmic index （CI） were significantly related to the depth of tumor invasion （P = 0.027, P = 0.020, respectively）, high indices being associated with increased depth of the primary tumor invasion （T3 and T4）. Similarly, patients with high α-catenin expression had a significantly increased risk of lymph node metastasis （32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI） （P = 0.001, P = 0.0001, respectively, for LNN status）. An altered expression （i.e., cytoplasmic pattern） was also related （P = 0.047） to the response to chemotherapy; patients with low CI were more responsive （CR： 7/46） than patients with high CI values （CR： 0/45）. There was a marginal effect on survival in patients time with metastases （SWM） （P = 0.087）; patients with low CI showing slightly longer SWM, but no such effect on disease free survival （DFS） or disease specific survival （DSS）. As to co-expression with another member of the adhesion complex （β-catenin）, high α-catenin/β-catenin MI index was of marginal significance in predicting longer DSS （P = 0.063, log-rank）. CONCLUSION： The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC.

关 键 词：Colorectal carcinoma ALPHA-CATENIN Membrane staining Cytoplasmic staining Prognosis 

分 类 号：R735.3[医药卫生—肿瘤]