两亲三元壳寡糖衍生物的合成及其包合物的研究  

Synthesis of Amphiphilic Ternary Chitooligosaccharide Derivatives and Theirs Inclusion Compounds

作　　者：赵三平[1] 曹孟杰[1] 徐卫林[1] 

机构地区：[1]武汉科技学院新型纺织材料学院,绿色加工及其功能化教育部重点实验室,武汉430073

出　　处：《高等学校化学学报》2008年第9期1914-1916,共3页Chemical Journal of Chinese Universities

基　　金：湖北省青年杰出人才基金(批准号:2007ABB033)资助

摘　　要：Novel water-soluble amphiphilic ternary graft copolymers(COS-g-PCL-b-MPEG) were synthesized by N,N′-dicyclohexyl carbodiimide(DCC) coupling reaction between chitooligosaccharide(COS) with MPEG-b-PCL-COOH,which was synthesized via ring-opening polymerization of ε-caprolactone(CL) with methoxy poly(ethylene glycol)(MPEG) as an initiator and subsequent carboxylation by succinic anhydride.The che-mical composition of the graft copolymers was studied by 1H NMR spectrum.In aqueous solutions,stable supramolecular hydrogels could be rapidly fabricated via the inclusion compound between the MPEG-b-PCL graft of COS derivates and α-CD.The supramolecular structure of the hydrogels was revealed by WXRD analysis.The temperature sweep test results show that no gel-sol transition temperature appears over the range from 20 ℃ to 60 ℃ for the obtained hydrogels.Novel water-soluble amphiphilie ternary graft copolymers （COS-g-PCL-b-MPEG） were synthesized by N, N＇-dicyclohexyl carbodiimide （DCC） coupling reaction between chitooligosaccharide （COS） with MPEG- b-PCL-COOH, which was synthesized via ring-opening polymerization of ε-caprolactone （CL） with methoxy poly（ethylene glycol）（MPEG） as an initiator and subsequent carboxylation by succinic anhydride. The chemical composition of the graft copolymers was studied by ^1H NMR spectrum. In aqueous solutions, stable supramolecular hydrogels could be rapidly fabricated via the inclusion compound between the MPEG-b-PCL graft of COS derivates and α-CD. The supramolecular structure of the hydrogels was revealed by WXRD analysis. The temperature sweep test results show that no gel-sol transition temperature appears over the range from 20 ℃ to 60 ℃ for the obtained hydrogels.

关 键 词：三元接枝共聚物 偶联反应 包合作用 超分子水凝胶 

分 类 号：O633.11[理学—高分子化学]