^99Tc-亚甲基二膦酸盐治疗多发性骨转移癌的临床观察  

Clinical study of ^99Tc-MDP in the treatment of multiple bone metastases cancer

作　　者：尹刘[1] 姚春梅[1] 况成国[1] 罗莉[1] 

机构地区：[1]蚌埠医学院附属淮北矿工总医院肿瘤放疗科,安徽省淮北235000

出　　处：《中国基层医药》2008年第8期1275-1276,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察^99Tc-亚甲基二膦酸盐（云克，^99Tc-MDP）对恶性肿瘤骨转移所至疼痛的治疗效果以及^99Tc-MDP对人体Hb、WBC、血小板（PLT）、血清钙及Ps评分的影响。方法选择恶性肿瘤多发骨转移患者78例给予^99Tc-MDP治疗。云克200mg加入0．9％氯化钠注射液500ml，缓慢静脉滴注2h，每天1次，连续使用5d。休息21～28d，重复第2个周期。每例患者不少于3个周期。结果^99Tc-MDP对Hb、WBC、PLT治疗前后无影响，但对治疗前后的血清钙有明显的影响，可以显著降低高血钙（P〈0．01）。对疼痛程度的缓解在治疗前后差异有统计学意义（P〈0．05）。对人体力状况PS改善情况在治疗前后变化不明显，差异无统计学意义（P〉0．05）。结论^99Tc-MDP治疗骨转移癌有一定的疗效，可以缓解骨转移癌引起的疼痛，对降低骨转移引起的高钙血症有一定作用。使用过程中未发生骨髓功能的抑制，无明显的消化道反应。Objective To observe the effect of ^99Tc-MDP in the treatment of metastasis bone disease pain with malignancies, and the influence of ^99Tc-MDP to human body＇s Hb, WBC, PLT, serum calcium, and PS grade. Methods ^99Tc-MDP was used for the treatment of bone metastases in 78 cases with malignancies; established the intravenous access,mainlined with the ^99Tc-MDP,200mg, the diluted physiological brine, and in two hours,once a day for five days. After the rest of twenty one to twenty-eight days, the second cycle was repeated, and each patient at least three cycles. Results ^99Tc-MDP had no influence to the Hb,WBC and PLT in pre-treatment and post-treatment, but had obvious effect on the serum calcium, the hypoealcaemia reduced obviously（ P 〈 0.01 ）. There was significant difference in ameliorating ache during the periods of pretreatment and post-treatment（P 〈 0.05）. However, there was no marked improvement in PS,and no statistic difference（P 〉0.05）. Conclusion ^99Tc-MDP has definite curative effect in the treatment of metastasis bone cancer, can ameliorate the ache induced by it, and can reduce the hypocalcaemia. There is no marrow inhibition and enteron reaction in the application.

关 键 词：^99Tc-锝美罗酸盐 骨肿瘤 肿瘤转移 

分 类 号：R73[医药卫生—肿瘤]