螺旋CT和基质金属蛋白酶-9诊断食管癌浸润和转移的价值比较  

Comparison of 16-slice spiral CT and MMP-9 in diagnosis of invasion and metastasis in human esophageal cancer

作　　者：王宏远[1] 隋林[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院CT室,黑龙江省哈尔滨150081

出　　处：《中国基层医药》2008年第8期1337-1338,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的比较螺旋CT扫描和基质金属蛋白酶-9（MMP-9）检测对肿瘤细胞浸润和转移的判断价值。方法对38例食管癌患者进行螺旋四检查，并用免疫组织化学法检测肿瘤组织中MMP-9的表达，比较两种方法的检查结果。结果病理确诊12例患者邻近组织受侵，螺旋CT检查出11例、MMP-9诊断出13例：病理确诊13例患者淋巴结发生转移，螺旋CT检查出12例、MMP-9诊断出16例；螺旋CT和MMP-9判断邻近组织是否受侵、淋巴结发生转移的阳性率、敏感度、准确度、特异度和诊断符合率差异均无统计学意义（P〉0．05）。结论螺旋CT检查是食管癌诊断的重要手段，在判断肿瘤浸润和转移方面具有不可替代的优势。Objective To compare the clinical values of 16-slice spiral computed tomography（CT） and matrix metalloproteinases-9（MMP-9） in diagnosis of invasion and metastasis in human esophageal cancer. Methods Thirty-eight patients with esophageal cancer were detected with spiral CT, and their tumor tissues were detected for expression of-MMP-9. Results 12 cases were diagnosed for vicinitic tissues damages by histopathological examination,while 11 cases were regarded to be damaged by CT and 13 cases were done according to MMP-9 determination; as to metastasis,there were 13 casese by histopathological examination,12 cases by CT and 16 cases by MMP-9 determination. No statistical difference were observed in diagnosis of vicinitic tissues damages anti metastasis by the three methods in positive rates, sensitivity, accuracy, specificity and diagnosis accordance rates （ P 〉 0.05; ）, Conclusion It is the important method for spiral CT in diagnosis of esophageal cancer, which could not be replaced by others in judgement of invasion and metastasis.

关 键 词：食管肿瘤 体层摄影术 x线计算机 基质金属蛋白酶-9 

分 类 号：R735[医药卫生—肿瘤] R730[医药卫生—临床医学]