脑梗死患者颈动脉粥样硬化的危险因素分析  

A Study on risk factors of carotid atherosclerosis in patients with acute ischemic stroke.

作　　者：潘元美[1] 李焰生[1] 林岩[1] 

机构地区：[1]上海交通大学医学院附属仁济医院神经内科,上海200127

出　　处：《中国神经精神疾病杂志》2008年第9期546-549,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市科委重大攻关项目(编号:03DZ13704)

摘　　要：目的探讨急性脑梗死患者颈动脉粥样硬化的危险因素以及影响斑块稳定性的因素。方法入选2005～2006年间住院的急性脑梗死患者644例，超声检查其颈动脉内膜-中层厚度（intima—media thickness，IMT）及颈动脉斑块情况，并与血管性危险因素和代谢因素进行相关分析。结果年龄、吸烟、糖尿病史、收缩压、总胆固醇及血清尿酸增高与颈动脉IMT增厚存在独立相关性，而年龄、收缩压、总胆固醇及脂蛋白（a）增高则可独立预测颈动脉斑块的形成。性别、高血压史、总胆固醇及高密度脂蛋白和颈动脉斑块的稳定性之间存在独立相关性。结论年龄、吸烟、糖尿病史、收缩压、总胆固醇、脂蛋白（a）及血清尿酸增高可独立预测颈动脉粥样硬化。Objective To investigate the risk factors of carotid atherosclerosis and the determinants of carotid plaque stability in patients with acute ischemic stroke. Methods The study included 644 patients with acute ischemic stroke in our hospital during2005 - 2006. Carotid IMT and plaques were assessed by B-mode ultrasound. The relationship of vascular risk factors and metabolic factors with carotid IMT and plaques was analyzed. Results Age, smoking, systolic blood pressure, diabetes mellitus, total cholesterol and serum uric acid were independently associated with carotid IMT thickening and age, systolic blood pressure, total cholesterol, and lipoprotein （a） were independent predictors of carotid plaques. There were independent associations of sex, hypertension, lipeprotein （a） and HDL with stability of carotid plaques. Conclusions The present study indicates that age, smoking, systolic blood pressure, diabetes mellitus, total cholesterol, lipoprotein（a） and serum uric acid are independent predictors of carotid atherosclerosis.

关 键 词：颈动脉粥样硬化 IMT 颈动脉斑块 稳定性 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]