尿苷二磷酸葡萄糖转移酶基因多态性与肿瘤遗传易感性研究进展  

Review on gene polymorphisms of UDP-glucuronosyltransferases and genetic susceptibility of cancer

作　　者：王亚东[1] 郑玉新[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《卫生研究》2008年第5期629-632,共4页Journal of Hygiene Research

基　　金：国家973计划项目资助项目(No.2002CB512903);国家杰出青年基金项目(No.30625031);国家自然科学基金资助项目(No.30700659)

摘　　要：尿苷二磷酸葡萄糖转移酶是生物体内重要的Ⅱ相代谢酶,它催化多种内源性和外源性化学物的代谢。根据基因结构、组织表达和底物特异性可将尿苷二磷酸葡萄糖醛酸转移酶分为肝外和肝内表达酶。研究表明尿苷二磷酸葡萄糖醛酸转移酶基因存在大量多态性位点,一些位点改变将影响酶的活性,进而影响酶对化学致癌物的代谢。因此,尿苷二磷酸葡萄糖醛酸转移酶基因多态性最终影响机体发生肿瘤的危险性,如结肠癌、乳腺癌、肺癌、近端消化道肿瘤、肝癌和前列腺癌。本文就尿苷二磷酸葡萄糖醛酸转移酶基因多态性与肿瘤遗传易感性关系作一综述。UDP-glucuronosyltransferases（UGT） are importmant phase Ⅱ metabolizing enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics.Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to their substrate specificity,tissue expression and gene structure.Genetic polymorphisms have been identified for almost all the UGT family members.Some Polymorphisms of UGT gene had an effect on the activity of UGT enzymes,then influenced the glucuronidation against cancer-related substrates,ultimately affected the genetic toxicity and carcinogenesis induced by cancer-related substrates.Numerous studies reported that polymorphisms of UGT gene were associated with the risk of several kinds of cancer,such as colorectal cancer,breast cancer,lung cancer,proximal digestive tract cancer,hepatocellular carcinoma and prostate cancer.This review examines in detail each UGT isozyme known to be associated with cancer.

关 键 词：尿苷二磷酸葡萄糖转移酶 肿瘤 基因多态性 

分 类 号：Q555.7[生物学—生物化学] R730.2[医药卫生—肿瘤]