羧甲基壳聚糖钙对小鼠补钙功能的研究  

EFFECT OF CARBOXYMETHYL CHITOSAN CALCIUM ON CALCIUM STATUS IN MICE

作　　者：赵秀香[1] 蔡文娣[2] 韩宝芹[3] 王常红[3] 刘万顺[3] 初金鑫[3] 

机构地区：[1]山东省胸科医院,济南250013 [2]潍坊医学院 [3]中国海洋大学生命学院

出　　处：《现代预防医学》2008年第19期3695-3696,3701,共3页Modern Preventive Medicine

基　　金：国家"十五"科技攻关项目(2001BA708B04-07)

摘　　要：[目的]探讨羧甲基壳聚糖钙对小鼠有无补钙作用。[方法]将一级昆明种小鼠随机分为低钙对照组、碳酸钙组及其羧甲基壳聚糖钙低、高剂量实验组,均自由进食基础饲料,同时灌胃给予受试物。实验第3周进行3d的钙代谢实验。连续30d后,采血,取肝脏、股骨,测得骨长及骨重,用原子吸收分光光度计测定其钙、锌含量。[结果]羧甲基壳聚糖钙试验组小鼠的骨钙含量、股骨重量显著高于对照组且不低于相应剂量的碳酸钙组,钙的吸收率不低于碳酸钙组。[结论]羧甲基壳聚糖钙具有一定的补钙功效。[Objective] To investigate the effect of supplementing calcium of carboxymethyl chitosan calcium （CCC） in mice. [Methods] Mice were randomly divided into 4 groups including low calcium control group, CaCO3 group, two experimental groups treated with CCC at two different doses. All mice were fed with Ca-deficient diet. At the same time CaCO3 and CCC were administrated to mice i.g. once a clay. During the third week, 3 days calcium metabolism test was done. 30 days later, mice were killed and the concentration of calcium and zincum m blood, liver and femur were determined by atomic absorption spectrophotometer. [Results ] The bone calcium, femoral bone weight were obviously better in CCC experimental groups than those in Ca-deficient group, and not lower than in CaCO3 group with the same dose. The absorption rate of CCC was not lower than CaCO3. [Conclusion] CCC has certain effect of supplementing calcium in mice.

关 键 词：羧甲基壳聚糖钙 小鼠 股骨 钙 

分 类 号：R151.2[医药卫生—营养与食品卫生学]