Alzheimer型痴呆的单光子发射型计算机断层扫描脑血流量测定的研究  

Study on cerebral blood flow of patients with dementia of Alzheimer type

作　　者：周久贸[1] 刘浩[1] 李亚明[1] 韩春起[1] 李德顺[1] 

机构地区：[1]中国医科大学附属第一医院核医学科,辽宁省沈阳市110001

出　　处：《实用老年医学》2008年第5期349-351,共3页Practical Geriatrics

摘　　要：目的99Tcm-双半胱乙酯(99Tcm-ECD)单光子发射型计算机断层扫描(single photon emission computed tomography,SPECT)脑血流灌注显像测定Alzheimer型痴呆(dementia of Alzheimer type,DAT)患者脑血流量(CBF)的价值。方法用NINCDS-ADRDA(national institute of neurological and communicative disorders and stroke and the Alzheimer’s disease and related disorders association)推荐的DAT诊断标准对以健忘为主诉来院检查的患者进行诊断,分为可能的DAT患者组(A组)14例,很有可能的DAT患者组(B组)21例,并设置正常对照组11例,进行99Tcm-ECD SPECT脑血流灌注显像,对其平均及局部CBF进行对比分析。结果B组DAT患者平均脑血流较正常对照有明显降低,局部脑血流表现为A组病人双侧顶叶、海马回、单侧颞叶中下回、颞极血流降低区;B组患者双侧额叶、颞叶、顶叶、枕叶血流明显下降。结论99Tcm-ECD SPECT脑血流灌注显像测定CBF是一种非侵袭性、简便可靠的方法,对DAT的诊断有一定的临床价值。Objective To evaluate the value of cerebral blood flow （CBF） imaging detected by ^99Tc^m-ECD SPECT in patients with dementia of Alzheimer type （DAT）. Methods Fourteen patients with possible DAT （ group A） , 21 patients with probable DAT （group B） and 11 healthy persons （control group） were included in our study. DAT patients were diagnosed by NINCDS-ADRDA criteria of DAT. All subjects underwent ^99Tc^m-ECD SPECT scanning. The images of each group were analyzed to quantify mean cerebral blood flow （mCBF） and regional cerebral blood flow （rCBF）. Resuits The mCBF values of group B were significantly lower than those of control group （P 〈 0.01 ）. The rCBF results showed that the ischemie areas of group A were found in both sides of occipital lobe and hippocampal gyrus, haft side of temporal lobe. While both sides of frontal lobe, temporal lobe, parietal lobe and occipital lobe had a low rCBF in group B. Conclusions The ^99Tc^m-ECD SPECT CBF imaging is a non-invasive, simple and reliable method for the diagnosis of DAT.

关 键 词：ALZHEIMER型痴呆 脑血流量 单光子发射计算机断层扫描 脑血流灌注显像 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]