慢性脑供血不足血栓前状态标志物水平变化及用药干预后的影响  

The Influence on The Prethrombotic State Markers in Chronic Cerebral Ischemia and Intervention with Drugs

作　　者：李东芳[1] 李光来[1] 连霞[1] 薛国芳[1] 朱爱萍[1] 郑辑英[1] 

机构地区：[1]山西医科大学第二医院

出　　处：《中西医结合心脑血管病杂志》2008年第10期1170-1172,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨慢性脑供血不足(CCCI)患者是否存在血栓前状态及药物干预对血栓前状态标志物水平的影响。方法根据日本2000年修订的CCCI诊断标准选择研究对象90例,将其分为基础治疗组(A组)、养血清脑颗粒组(B组)、联合用药组(C组)各30例,同时选正常对照组(D组)27名,用药前后测定一氧化氮(NO)、血管内皮素-1(ET-1)、纤维蛋白原(FIB)、Ⅰ型纤溶酶原激活物抑制物(PAI-1)及组织型纤溶酶原激活物(t-PA)水平。结果A组、B组、C组治疗前分别与D组比较,NO、t-PA水平降低,ET-1、PAI-1、FIB水平升高(P<0.05或P<0.01);B组、C两组治疗后各检测指标水平较治疗前均有统计学意义(P<0.01)。治疗后,B组、C组与A组各检测指标比较均有统计学意义(P<0.05或P<0.01)。结论CCCI患者存在血栓前状态,而养血清脑颗粒能改善血栓前状态的各指标。Objective To explore whether or not there was prethrombotie state in the patients （pts） with chronic cerebral circula- tion insufficiency （CCCI） and effect of drugs intervention. Methods Ninety pts with CCCI selected according to the diagnostic criteria of CCCI revised in Japan 2000 were divided into three groups： Group A （n= 30） treated by basic method, group B （n= 30） treated with Yangxueqingnao granule, and group C （n= 30） with drug combination therapy. Twenty-two healthy subjects were selected as control group （group D）. Levels of serum nitric oxide （NO）, endothelin - 1 （ET - 1）, fibrinogen （FIB）, plasminogen activator inhibitor - 1 （PAI- 1 ） and tissue plasminogen activator（t - PA） were tested and analyzed pre - and post - therapy. Results The levels of serum NO and t- PA in group A, B, C were lower compared with that in group D, and levels of serum ET- t, PAI- 1 and FIB were high（P^0. 05 or P〈0. 01） before treatment. There were no differences of levels of these serum markers in group A preand post - therapy. But levels of these markers in groups B and C showed significant differences （P〈0.01）. Following the treatment, the differences of all the indexes in groups B and C were different significantly compared with that in group A （P〈0.05 or P〈0.01）. Conclusion There was a prethrombotic state in pts with CCCI. Yangxueqingnao granule could improve index of pretbromhotie state.

关 键 词：慢性脑供血不足 血栓前状态 养血清脑颗粒 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]